Interactions between alpha-ketoisovalerate metabolism and the pathways of gluconeogenesis and urea synthesis in isolated hepatocytes.
Ángeles Martín-Requero,Barbara E. Corkey,Sebastián Cerdán,E Walajtys-Rode,Roberto L. Parrilla,John R. Williamson +5 more
TLDR
Direct effects of various acyl-CoA metabolites on these key enzymes may explain symptoms of hypoglycemia and hyperammonemia observed in patients with inherited disorders of organic acid metabolism.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-03-25 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Pyruvate decarboxylation & Pyruvate dehydrogenase complex.read more
Citations
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Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?
TL;DR: The Banting Medal for Scientific Achievement is the American Diabetes Association's highest scientific award and honors an individual who has made significant, long-term contributions to the understanding of diabetes, its treatment, and/or prevention.
Journal ArticleDOI
Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria.
TL;DR: It is demonstrated that carnitine can modulate the aliphatic short-chain acyl-CoA/CoA ratio in heart and liver mitochondria and indicate that the degree of modulation varies with theAliphatic acyl moiety.
Journal ArticleDOI
Propionyl-CoA carboxylase – A review
TL;DR: An overview of the current knowledge about the structure and function of PCC is presented and an updated list of human variants which are published is reviewed to provide an overview ofThe disease.
Journal ArticleDOI
Metabolism of citrulline in man.
D. Rabier,P. Kamoun +1 more
TL;DR: This review described these pathways and their regulation in different tissues, trying to explain the physiological and pathological (inherited or acquired) variations in man.
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Clinical and biochemical aspects of primary and secondary hyperammonemic disorders
TL;DR: The biochemical background of primary and secondary hyperammonemia is discussed and an overview of the various underlying conditions including a brief clinical outline and information on the genetic backgrounds are given.
References
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Book
Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
Book ChapterDOI
[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods
TL;DR: This chapter is based on the assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods based on instruments capable of giving a full-scale deflection of the recorder with 0.25μM NADH, with a noise level less than 2%.
Journal ArticleDOI
Control Mechanisms of Gluconeogenesis and Ketogenesis I. EFFECTS OF OLEATE ON GLUCONEOGENESIS IN PERFUSED RAT LIVER
TL;DR: Oleate increased the state of reduction of the pyridine nucleotide systems in both mitochondrial and cytosolic spaces as shown by increases in the ratios of lactate to pyruvate, β-hydroxybutyrate to acetoacetate, and malate to oxalacetate.
Book ChapterDOI
Concentrations of Metabolites and Binding Sites. Implications in Metabolic Regulation
Alberto Sols,R. Marco +1 more
TL;DR: This chapter discusses the implications in metabolic regulation because of the concentrations of metabolites and binding sites in the eukaryotic cell of higher organisms, in which practically all important metabolic reactions occur.
Journal ArticleDOI
Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats.
TL;DR: Hematocytes isolated from fed or starved rats were rapidly lysed using the recently described technique of turbulent flow to evaluate the mass action ratios of both cytosolic and mitochondrial enzymes.
Related Papers (5)
Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids.
Eric P. Brass,R A Beyerinck +1 more