Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria.
TLDR
It is demonstrated that carnitine can modulate the aliphatic short-chain acyl-CoA/CoA ratio in heart and liver mitochondria and indicate that the degree of modulation varies with theAliphatic acyl moiety.About:
This article is published in Journal of Biological Chemistry.The article was published on 1988-01-25 and is currently open access. It has received 140 citations till now. The article focuses on the topics: Carnitine-acylcarnitine translocase & Carnitine.read more
Citations
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Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
TL;DR: It is now clear that metabolic interventions aimed at enhancing glucose utilisation and pyruvate oxidation at the expense of fatty acid oxidation is a valid therapeutic approach to the treatment of myocardial ischaemia.
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Regulation of fatty acid oxidation in the mammalian heart in health and disease.
TL;DR: Endogenous triacylglycerol as a source of fatty acids and Carnitine palmitoyltransferase 1 activity and Acetyl-CoA carboxylase regulation of fatty acid oxidation.
Journal ArticleDOI
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
TL;DR: It is concluded that ACC is an important regulator of fatty acid oxidation in the heart and that acetyl-CoA supply is a key determinant of heart ACC-280 activity.
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Control of mitochondrial beta-oxidation flux.
TL;DR: The sharing of control between CPTI and other enzymes allows for flexible regulation of metabolism and the ability to rapidly adapt beta-oxidation flux to differing requirements in different tissues.
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Energy metabolism in the normal and failing heart: potential for therapeutic interventions.
TL;DR: It is suggested that chronic manipulation of myocardial substrate oxidation toward greater carbohydrate oxidation and less fatty acid oxidation may improve ventricular performance and slow the progression of left ventricular dysfunction in heart failure patients.
References
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A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250
TL;DR: An assay for proteins in solution that depends on the conversion of Coomassie brilliant blue G250 in dilute acid from a brownish-orange to an intense blue color has high reproducibility and can detect less than 1.0 μg of albumin.
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Carnitine--metabolism and functions
TL;DR: The only firmly established function of carnitine is its function as a carrier of activated fatty acids and activated acetate across the inner mitochondrial membrane, and the regulation of its synthesis is still incompletely understood.
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Coenzyme A and carnitine distribution in normal and ischemic hearts.
TL;DR: The percentage of the total cellular carnitine associated with the mitochondria increased from 8 to 9% in nonperfused and control hearts to 25% during ischemia, indicating that a net transfer of carnitines occurred from the cytosol to the mitochondrial matrix.
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Carnitine and derivatives in rat tissues.
D. J. Pearson,P. K. Tubbs +1 more
TL;DR: Comparison of the acetylation states of carnitine and CoA in perfused hearts suggests that the carn itine acetyltransferase reactants may remain near equilibrium despite wide variations in their steady-state concentrations.
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Active transport of butyrobetaine and carnitine into isolated liver cells
TL;DR: The data indicate the existence of a common carrier in the plasma membrane which mediates the uphill transport of both carnitine and butyrobetaine.
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Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
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