Journal ArticleDOI
Intermediates and barrier crossing in a random energy model (with applications to protein folding)
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In this paper, a simple generalisation of the theory of l'etat de transition is proposed for estiming le temps de repliement d'une proteine.Abstract:
Utilisation d'un hamiltonien stochastique pour etudier une reaction chimique complexe. Une simple generalisation de la theorie de l'etat de transition est developpee et est utilisee pour estimer le temps de repliement d'une proteineread more
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Journal ArticleDOI
The energy landscapes and motions of proteins.
TL;DR: The concepts that emerge from studies of the conformational substates and the motions between them permit a quantitative discussion of one simple reaction, the binding of small ligands such as carbon monoxide to myoglobin.
Journal ArticleDOI
Funnels, pathways, and the energy landscape of protein folding: A synthesis
TL;DR: The work unifies several previously proposed ideas concerning the mechanism protein folding and delimits the regions of validity of these ideas under different thermodynamic conditions.
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From Levinthal to pathways to funnels
Ken A. Dill,Hue Sun Chan +1 more
TL;DR: The general energy landscape picture provides a conceptual framework for understanding both two-state and multi-state folding kinetics and hopes to learn much more about the real shapes of protein folding landscapes.
Journal ArticleDOI
THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
TL;DR: The energy landscape theory of protein folding suggests that the most realistic model of a protein is a minimally frustrated heteropolymer with a rugged funnel-like landscape biased toward the native structure.
Journal ArticleDOI
Principles of protein folding--a perspective from simple exact models.
Ken A. Dill,Sarina Bromberg,Kaizhi Yue,Klaus M. Fiebig,David P. Yee,Paul Thomas,Hue Sun Chan +6 more
TL;DR: These studies suggest the possibility of creating “foldable” chain molecules other than proteins, and can account for the properties that characterize protein folding: two‐state cooperativity, secondary and tertiary structures, and multistage folding kinetics.