Open Access
International study of the prevalence and outcomes of infection in intensive care units
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The article was published on 2009-01-01 and is currently open access. It has received 1064 citations till now. The article focuses on the topics: Intensive care.read more
Citations
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Journal ArticleDOI
Severe sepsis and septic shock
Derek C. Angus,Tom van der Poll +1 more
TL;DR: A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
Journal ArticleDOI
Epidemiology of severe sepsis.
TL;DR: People of older age, male gender, black race, and preexisting chronic health conditions are particularly prone to develop severe sepsis; hence prevention strategies should be targeted at these vulnerable populations in future studies.
Journal ArticleDOI
Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
Janaina de Cássia Orlandi Sardi,Liliana Scorzoni,T Bernardi,A. M. Fusco-Almeida,M J S Mendes Giannini +4 more
TL;DR: A brief review of the literature regarding the epidemiology of Candida species, as well as their pathogenicity and ability to form biofilms, the antifungal activity of natural products and other therapeutic options is presented.
Journal ArticleDOI
Sepsis and septic shock
Richard S. Hotchkiss,Lyle L. Moldawer,Steven M. Opal,Konrad Reinhart,Isaiah R. Turnbull,Jean Louis Vincent +5 more
TL;DR: With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of a long-term chronic critical illness, often associated with prolonged inflammation, immune suppression, organ injury and lean tissue wasting.
Journal ArticleDOI
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
Jason A. Roberts,Jason A. Roberts,Mohd H. Abdul-Aziz,Jeffrey Lipman,Jeffrey Lipman,Johan W. Mouton,Alexander A. Vinks,Timothy Felton,William W. Hope,Andras Farkas,Michael Neely,Jerome J. Schentag,George L. Drusano,Otto R Frey,Ursula Theuretzbacher,Joseph L. Kuti +15 more
TL;DR: The challenges related to patients and pathogens that contribute to inadequate antibiotic dosing are explored and how to implement a process for individualised antibiotic therapy that increases the accuracy of dosing and optimises care for critically ill patients is discussed.
References
More filters
Journal ArticleDOI
Severe sepsis and septic shock
Derek C. Angus,Tom van der Poll +1 more
TL;DR: A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
Journal ArticleDOI
Epidemiology of severe sepsis.
TL;DR: People of older age, male gender, black race, and preexisting chronic health conditions are particularly prone to develop severe sepsis; hence prevention strategies should be targeted at these vulnerable populations in future studies.
Journal ArticleDOI
Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
Janaina de Cássia Orlandi Sardi,Liliana Scorzoni,T Bernardi,A. M. Fusco-Almeida,M J S Mendes Giannini +4 more
TL;DR: A brief review of the literature regarding the epidemiology of Candida species, as well as their pathogenicity and ability to form biofilms, the antifungal activity of natural products and other therapeutic options is presented.
Journal ArticleDOI
Sepsis and septic shock
Richard S. Hotchkiss,Lyle L. Moldawer,Steven M. Opal,Konrad Reinhart,Isaiah R. Turnbull,Jean Louis Vincent +5 more
TL;DR: With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of a long-term chronic critical illness, often associated with prolonged inflammation, immune suppression, organ injury and lean tissue wasting.
Journal ArticleDOI
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
Jason A. Roberts,Jason A. Roberts,Mohd H. Abdul-Aziz,Jeffrey Lipman,Jeffrey Lipman,Johan W. Mouton,Alexander A. Vinks,Timothy Felton,William W. Hope,Andras Farkas,Michael Neely,Jerome J. Schentag,George L. Drusano,Otto R Frey,Ursula Theuretzbacher,Joseph L. Kuti +15 more
TL;DR: The challenges related to patients and pathogens that contribute to inadequate antibiotic dosing are explored and how to implement a process for individualised antibiotic therapy that increases the accuracy of dosing and optimises care for critically ill patients is discussed.
Related Papers (5)
Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study.
Marcio Soares,Fernando A. Bozza,Derek C. Angus,André M. Japiassú,William N. Viana,Roberto Costa,Leonardo Brauer,Bruno Franco Mazza,Thiago Domingos Corrêa,Andre Luiz Baptiston Nunes,Thiago Lisboa,Fernando Colombari,Alexandre Toledo Maciel,Luciano Cesar Pontes Azevedo,M Damasceno,Haggeas S Fernandes,Alexandre Biasi Cavalcanti,Pedro Emmanuel Alvarenga Americano do Brasil,Jeremy M. Kahn,Jorge I. F. Salluh +19 more