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Journal ArticleDOI

Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome.

TLDR
An observer agreement study in which two of eight intensivists and a radiologist, blinded to one another's interpretation, reviewed 778 radiographs from 99 critically ill patients concludes that intensivist without formal consensus training can achieve moderate levels of agreement.
Abstract
To measure the reliability of chest radiographic diagnosis of acute respiratory distress syndrome (ARDS) we conducted an observer agreement study in which two of eight intensivists and a radiologist, blinded to one another's interpretation, reviewed 778 radiographs from 99 critically ill patients. One intensivist and a radiologist participated in pilot training. Raters made a global rating of the presence of ARDS on the basis of diffuse bilateral infiltrates. We assessed interobserver agreement in a pairwise fashion. For rater pairings in which one rater had not participated in the consensus process we found moderate levels of raw (0.68 to 0.80), chance-corrected ( κ 0.38 to 0.55), and chance-independent ( Φ 0.53 to 0.75) agreement. The pair of raters who participated in consensus training achieved excellent to almost perfect raw (0.88 to 0.94), chance-corrected ( κ 0.72 to 0.88), and chance-independent ( Φ 0.74 to 0.89) agreement. We conclude that intensivists without formal consensus training can achiev...

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Journal ArticleDOI

Acute respiratory distress syndrome: the Berlin Definition.

TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI

Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.

TL;DR: Increased dead-space fraction is a feature of the early phase of the acute respiratory distress syndrome and Elevated values are associated with an increased risk of death.
Journal ArticleDOI

Toward an understanding of transfusion‐related acute lung injury: statement of a consensus panel

TL;DR: This Consensus Conference was funded by Canadian Blood Services and Hema-Quebec, with additional support from the International Society of Blood Transfusion’s Biomedical Excellence for Safer Transfusions (BEST) subcommittee.
References
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Journal ArticleDOI

The measurement of observer agreement for categorical data

TL;DR: A general statistical methodology for the analysis of multivariate categorical data arising from observer reliability studies is presented and tests for interobserver bias are presented in terms of first-order marginal homogeneity and measures of interob server agreement are developed as generalized kappa-type statistics.
Journal ArticleDOI

Weighted kappa: Nominal scale agreement provision for scaled disagreement or partial credit.

TL;DR: The Kw provides for the incorpation of ratio-scaled degrees of disagreement (or agreement) to each of the cells of the k * k table of joi.
Journal ArticleDOI

The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination

TL;DR: The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.

Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.

N. E. Breslow, +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
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