Journal ArticleDOI
Investigation of the Safety of Irreversible Electroporation in Humans
Kenneth R. Thomson,Wa Cheung,Samantha Ellis,Dean Federman,Helen Kavnoudias,Deirdre Loader-Oliver,Stuart K. Roberts,Peter Evans,Christine Ball,Andrew Haydon +9 more
TLDR
IRE appears to be safe for human clinical use provided ECG-synchronized delivery is used, and Comparative evaluation with alternative ablative technologies is warranted.About:
This article is published in Journal of Vascular and Interventional Radiology.The article was published on 2011-05-01. It has received 427 citations till now. The article focuses on the topics: Irreversible electroporation.read more
Citations
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Journal ArticleDOI
Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges
TL;DR: This review describes the theory and current applications of electroporation in medicine and then discusses current challenges in Electroporation research and barriers to a more extensive spread of these clinical applications.
Journal ArticleDOI
Irreversible electroporation for nonthermal tumor ablation in the clinical setting: a systematic review of safety and efficacy.
Hester J. Scheffer,Karin Nielsen,Marcus C. de Jong,Aukje A. J. M. van Tilborg,J.M. Vieveen,Arthur R A Bouwman,Sybren L. Meijer,Cornelis van Kuijk,Petrousjka van den Tol,Martijn R. Meijerink +9 more
TL;DR: Overall, the future of IRE for difficult-to-reach tumors appears promising, and in cases where other techniques are unsuitable, IRE is a promising modality for the ablation of tumors near bile ducts and blood vessels.
Journal ArticleDOI
Safety and early efficacy of irreversible electroporation for hepatic tumors in proximity to vital structures.
TL;DR: This study aims to evaluate the safety and efficacy of IRE for hepatic tumors in the clinical setting with a double-blind, placebo-controlled trial.
Journal ArticleDOI
High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction
Christopher B. Arena,Michael B. Sano,John H. Rossmeisl,John L. Caldwell,Paulo A. Garcia,Marissa Nichole Rylander,Rafael V. Davalos +6 more
TL;DR: H-FIRE is a feasible technique for non-thermal tissue ablation that eliminates muscle contractions seen in IRE treatments performed with unipolar electric pulses and has the potential to be performed clinically without the administration of paralytic agents.
Journal ArticleDOI
A Review of Basic to Clinical Studies of Irreversible Electroporation Therapy
TL;DR: This study reviews the in vitro, translational, and clinical studies of IRE cancer therapy based on major experimental studies particularly within the past decade and provides organized data and facts to assist further research, optimization, and patients' needs.
References
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Journal ArticleDOI
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
TL;DR: A simple physical model for the enhanced DNA penetration into cells in high electric fields is proposed, according to which the interaction of the external electric field with the lipid dipoles of a pore configuration induces and stabilizes the permeation sites and thus enhances cross membrane transport.
Journal ArticleDOI
Theory of electroporation: A review
TL;DR: This review of the essential features of theoretical models of electroporation focuses on transient aqueous pore models, which can account for key features of mechanical instability and dramatic reversible electrical behavior of certain planar membranes and of cell membranes, and some features of molecular transport.
PatentDOI
Tissue ablation with irreversible electroporation
Rafael V. Davalos,Boris Rubinsky +1 more
TL;DR: In this paper, a new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed, which involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the desired tissue.
Journal ArticleDOI
Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance.
Journal ArticleDOI
Early-Stage Hepatocellular Carcinoma in Patients with Cirrhosis: Long-term Results of Percutaneous Image-guided Radiofrequency Ablation
Riccardo Lencioni,Dania Cioni,Laura Crocetti,C. Franchini,Clotilde Della Pina,Jacopo Lera,Carlo Bartolozzi +6 more
TL;DR: RF ablation is an effective first-line treatment for cirrhotic patients with early-stage HCC who were excluded from surgery and who had Child class A or B cirrhosis with either a single HCC less than or equal to 5 cm in diameter or multiple (as many as three) HCCs less than and equal to 3cm in diameter each.