Journal ArticleDOI
Investigations into the antitumour activity of organotin compounds. 2. Diorganotin dihalide and dipseudohalide complexes
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The results of screening tests on 115 of the titled compounds against P388 lymphocytic leukaemia are reported and structure/activity relationships discussed in this article, where the authors discuss the relationship between drugs and their properties.About:
This article is published in Inorganica Chimica Acta.The article was published on 1984-12-01. It has received 147 citations till now.read more
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Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
TL;DR: Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved.
Journal ArticleDOI
Development of organometallic (organo-transition metal) pharmaceuticals
TL;DR: In this article, the authors introduce the organometallic chemist to the fascinating area of organometal pharmaceuticals, and describe the properties of transition metal compounds that lend themselves to medical applications.
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Complexes of metals other than platinum as antitumour agents.
TL;DR: Several platinum complexes and four non-platinum-metal antitumour agents have so far entered early clinical trials, and Gallium trinitrate and spirogermanium have shown limited cytostatic activity against certain human carcinomas and lymphomas.
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Metal compounds in cancer chemotherapy
Ionel Haiduc,Cristian Silvestru +1 more
TL;DR: In this paper, the synthetique de complexes metalliques utilisables en chimiotherapeutique is presented, and a bibliographique of the complex metallique is described.
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Journal ArticleDOI
Investigations into the antitumour activity of organotin compounds. I. Diorganotin dihalide and di-pseudohalide complexes
TL;DR: The antitumor activity of a series of diorganotin dihalide and di-pseudohalide complexes, R2SnX2, L2, where R = Methyl (Me), Ethyl (Et), n-Propyl (Pr, n-Butyl (Bu) or Phenyl (Ph), and L = O- or N- donor organic ligand, which were modelled on the active platinum complexes, has been investigated.
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Possible pre-dissociation of diorganotin dihalide complexes: Relationship between antitumour activity and structure
TL;DR: An examination of crystallographic data has indicated that the structure/activity relationship for diorganotin dihalide complexes is different from that of other metal dihalides, in that the Sn-N bond lengths appear to determine the antitumour activity.
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The synthesis and tin-119m mössbauer spectra of some diorganotin dihalide and dipseudohalide complexes with nitrogen- and oxygen-donor ligands
Alan J. Crowe,Pete Smith +1 more
TL;DR: In this article, the synthesis and 119m Sn Mossbauer spectra of 114 complexes of the type R 2 SnX 2, L 2 (R Me, Et, n-Pr, N-Bu, nOct, Ph, Bz, X ǫ, F, Cl, Br, I, NCS; L 2 2 monodentate or 1 bidentate O- or N-donor ligand(s), 74 of which are new, are reported.
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Antitumor activity of some diorganotin and tin(IV) complexes of Schiff bases.
Anil Saxena,Jagdish P. Tandon +1 more
TL;DR: Di-n-butyltin complex derived from salicylaldehyde-S-methyl dithiocarbazate has been found to be the most active in this series and display T/C values in the range 94-124.