Journal ArticleDOI
Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
TLDR
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed.Abstract:
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.read more
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Journal ArticleDOI
Outcomes of the Pediatric Development Plan of Tapentadol
TL;DR: In this article, the outcomes of the pediatric development program for tapentadol across the entire age range from birth (including neonates) to adolescents <18 years of age are discussed.
Journal ArticleDOI
Participation of ATP-sensitive K+ channels and μ-opioid receptors in the antinociceptive synergism of the paracetamol-tapentadol co-administration in the formalin-induced pain assay in mice.
Juan Ramón Zapata-Morales,Angel Josabad Alonso-Castro,Salud Pérez-Gutiérrez,Edgar Isaac Rojas-Bedolla,Sergio Sánchez-Enríquez,Jorge David Rivas-Carrillo,Nicolás Serafín-Higuera,Mario Alberto Isiordia-Espinoza +7 more
TL;DR: In this paper, the interaction and mechanisms of action of the paracetamol-tapentadol combination in the formalin-induced pain model in mice were assessed and the ED50 values were used to calculate the combinations in three fixed proportions (1:1, 1:3, and 3:1).
Journal ArticleDOI
Tapentadol prolonged release for severe chronic osteoarthritis pain in the elderly: improvements in daily functioning and quality of life.
TL;DR: Tapentadol PR is a useful strong analgesic to improve pain intensity, physical functioning and quality of life in elderly OA patients.
Journal ArticleDOI
Tapentadol: mit zwei Mechanismen in einem Molekül wirksam gegen nozizeptive und neuropathische Schmerzen : Präklinischer Überblick (Übersichten)
Thomas M. Tzschentke,Thomas Christoph,Wolfgang Schröder,W. Englberger,J. De Vry,U. Jahnel,B.Y. Kögel +6 more
TL;DR: Tapentadol (3-[(1R, 2R)-3-dimethylamino)-1-ethyl-2-methylpropyl] phenol is a centrally acting analgesic of a new substance class for the treatment of severe nociceptive and neuropathic pain this paper.
Journal ArticleDOI
Tolerability of concomitant use of selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors and oxymorphone extended release
TL;DR: The concomitant use of oxymorphone ER with SSRIs or SNRIs was well tolerated in patients with cLBP and Visual analog scale scores were similar in patients taking versus those not taking SSRI/SNRIs throughout the study.