Journal ArticleDOI
Iodide enhances IgG synthesis by human peripheral blood lymphocytes in vitro
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TLDR
Investigation of the effect of iodide in vitro at physiologically relevant concentrations on immunoglobulin synthesis by normal human peripheral blood lymphocytes stimulated with pokeweed mitogen suggests that iodides may have a role in enhancing antibody synthesis.Abstract:
Several studies have suggested that iodide may increase thyroiditis and autoantibody synthesis. We have investigated the effect of iodide in vitro at physiologically relevant concentrations on immunoglobulin synthesis by normal human peripheral blood lymphocytes stimulated with pokeweed mitogen. Both the number of cells which synthesised IgG and the amount of IgG released into the culture supernatant increased significantly after culture in a medium with added iodide compared to a medium with added chloride. No effect of increasing concentrations of the added iodide from 10(-3) mM to 10 mM was observed. These findings suggest that iodides may have a role in enhancing antibody synthesis which may be important when programmes of iodide supplementation are introduced into areas which are deficient.read more
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Journal ArticleDOI
Induction of Autoimmune Thyroiditis in Chickens by Dietary Iodine
TL;DR: Administration of iodine during the first 10 weeks of life increased the incidence of the disease, as determined by histology and the measurement of autoantibodies to triiodothyronine, thyroxine, and thyroglobulin.
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High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece.
Christos D. Zois,Ioanna Stavrou,Chrysoula Kalogera,Eugenia Svarna,Ioannis D. K. Dimoliatis,Konstantinos Seferiadis,Agathocles Tsatsoulis +6 more
TL;DR: The impact of silent iodine prophylaxis on the prevalence of autoimmune thyroiditis among schoolchildren in a formerly iodine-deficient community in northwestern Greece was investigated in this paper.
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More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels.
Xiaochun Teng,Zhongyan Shan,Yanyan Chen,Yaxin Lai,Jiashu Yu,Ling Shan,Xue Bai,Yuanbin Li,Ningna Li,Zhidan Li,Sen Wang,Qian Xing,Haibo Xue,Lin Zhu,Xin Hou,Chenling Fan,Weiping Teng +16 more
TL;DR: More than adequate iodine intake could be a public health concern in terms of thyroid function and thyroid autoimmunity in the Chinese populations.
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Evidence for an effect of antithyroid drugs on the natural history of graves' disease
TL;DR: It is proposed that antithyroid drugs may modify the natural history of Graves' disease and contribute to the remission which occurs in a proportion of treated patients.
Journal ArticleDOI
Iodide induces thyroid autoimmunity in patients with endemic goitre: a randomised, double-blind, placebo-controlled trial.
TL;DR: Although nearly comparable results were obtained with both treatment regimens regarding thyroid size, partly reversible iodine-induced thyroid dysfunction and autoimmunity were observed among patients with endemic goitre.