Showing papers in "The American Journal of Medicine in 1986"
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TL;DR: The mobility test, the best single predictor of recurrent falling, may be useful clinically because it is simple, recreates fall situations, and provides a dynamic, integrated assessment of mobility.
1,507Â citations
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TL;DR: Results confirm the hypothesis that the favorable effect of auranofin on clinical synovitis is accompanied by improvements across a range of outcomes relevant to the patient's quality of life.
351Â citations
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TL;DR: A special constellation of elevated triglycerides, low high-density lipoprotein levels, and "normal" cholesterol values should no longer be overlooked in assessing coronary heart disease risk.
346Â citations
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TL;DR: Evidence suggests that limitation of dietary protein intake delays the development of age- and disease-related glomerular sclerosis in experimental animals, and that dietary protein restriction may postpone end-stage renal disease in patients with progressive renal insufficiency.
330Â citations
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TL;DR: Experimental exposure of volunteers to moving air at 41 degrees C for six hours caused core temperature to rise 0.84 degree C, weight to fall 1.83 kg with sweating despite access to water, heart rate to increase 32 beats per minute, and arterial pressure to fall, particularly on standing.
329Â citations
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TL;DR: Findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein.
323Â citations
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TL;DR: Multiple factors, including altered levels of vasoactive substances, altered vasomotor responsiveness, chronic plasma volume expansion, and tissue hypoxia, contribute to a state of generalized microvascular vasodilatation in early insulin-dependent diabetes mellitus, with the consequent elevation in capillary pressures and flows.
322Â citations
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TL;DR: Serum cryptococcal antigen levels were as high as 1:2,000,000 and, despite therapy, often remained elevated andAntigen titers in the cerebrospinal fluid generally declined at an expected rate in the survivors.
298Â citations
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TL;DR: It is suggested that in selected patients with left ventricular dysfunction, coronary artery bypass surgery can be performed with acceptable mortality and may result in symptomatic and functional benefit.
274Â citations
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TL;DR: The most critical factor in recovery from fungal infection is remission of the underlying malignant disease, and the most important prognostic factor is whether or not the neutrophil count recovers during the course of infection.
274Â citations
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TL;DR: Multivariate statistical analysis showed that neutropenia and absence of cigarette smoking were significant predictors of invasive aspergillosis in patients with respiratory tract cultures yielding Aspergillus.
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TL;DR: The etiology and pathogenesis of osteoarthritis is reviewed, particularly one of several current concepts concerning the possible central mechanisms regulating degradation of cartilage, which involves diffuse or focal exposure of the extracellular matrix to active neutral metalloproteinases.
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TL;DR: The mechanism of action of buspirone challenges the notion that only one neurotransmitter mediates anxiety, and suggests thatBuspirone may alter diverse activities within a "neural matrix of anxiety."
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TL;DR: Factors potentially associated with adult-onset diabetes mellitus in the elderly were reviewed, using the Framingham Heart Study data and other population data, finding that Hypertension and coexistent vascular disease were particularly common in elderly diabetic patients.
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TL;DR: It is demonstrated that the renin response to oral captopril is a useful screening test for identifying patients with unilateral or bilateral renovascular disease and since the test also characterizes the ren in dependency of the hypertension, it may have other diagnostic and therapeutic uses.
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TL;DR: Enteral nutrition can be associated with gastric flora colonizing the trachea and causing nosocomial respiratory infection, and multiple sources of tracheal colonization occur in patients receiving enteral nutrition.
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TL;DR: It is concluded that the HLA-DR2 antigen and the C4A null allele are independent and additive risk factors for development of SLE.
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TL;DR: The pharmacokinetics of buspirone were not significantly different in men and women or in individuals 21 to 40 years old compared with those over 65 years of age and co-administration of amitriptyline or diazepam did not alter the disposition of these agents or their demethylated metabolites.
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TL;DR: Correcting the formula for measurement of free water excretion allows solute and water intake and excretion to be compared, thereby leading to a better understanding of both the development and correction of disturbances in the plasma sodium level.
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TL;DR: It is concluded that acute promyelocytic leukemia is a unique disease with a high potential for cure and knowledge of its prognosis using present frontline and salvage therapy, of the factors related to fatal hemorrhage, and of the unusual patient marrow profiles during remission induction may improve the therapeutic approach.
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TL;DR: An increase in the number of cases of gram-negative ventriculomeningitis in patients followed with intracranial pressure monitors when compared with patients with craniotomy alone was revealed by routine surveillance data.
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TL;DR: Many types of cells are activated and transformed in rheumatoid synovium, thereby contributing to amplification of the disease process, and many products of inflammation act as mediators, driving proliferation of synovial cells.
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TL;DR: The use of seronegative blood products is highly effective in preventing primary cytomegalovirus infection among ser onegative patients and trimethoprim/sulfamethoxazole prophylaxis has been associated with a lower risk of infection among patients being treated for chronic GVHD.
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TL;DR: It is demonstrated that empiric use of vancomycin reduces the morbidity of gram-positive infections following intensive antileukemic therapy and decreases the need for empirical use of toxic amphotericin B.
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TL;DR: Study of appropriate cell systems demonstrates that diclofenac's potent inhibition of cyclo-oxygenase activity causes a sharp reduction in the formation of prostaglandin, prostacyclin, and thromboxane products, all key mediators of inflammation.
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TL;DR: Multivariate analyses using mortality and sudden death as endpoints revealed that a cardiovascular cause of syncope was a very strong risk factor in patients with a noncardiovascular cause or unknown cause of Syncope.
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TL;DR: Bacteriuria is common in the elderly and appears related to functional status, however, the turnover of infected and noninfected subjects was high, and surprisingly, persistence was not found in most.
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TL;DR: Findings portray normal pregnancy as a state of physiologic absorptive hypercalciuria and call into question the widespread practice of supplementing calcium intake in otherwise well-nourished women during pregnancy.