Journal ArticleDOI
Iodine and the thyroid hormones
TLDR
The retention of thyromimetic activity when alkyl groups replace the halogens in triiodothyronine requires a re-examination of the relationship between iodine and the thyroid hormones.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1981-01-01. It has received 10 citations till now. The article focuses on the topics: Thyroid peroxidase & Iodine in biology.read more
Citations
More filters
Book
Biochemistry of the Elemental Halogens and Inorganic Halides
TL;DR: The elements in group 17 (VIlA) of the periodic table of elements-fluorine (F), chlorine (CI), bromine (Br), and iodine (I)-were designated by Berzelius as "halogens" (Greek halogens) because of their propensity to form salts.
Journal ArticleDOI
Clinical implications of trace elements in endocrinology
TL;DR: The implications of essential trace elements in endocrinological processes, mainly thyroid function, growth, gonadal function, adrenal hormones, prolactin, glucose homeostasis, calcium-phosphorus metabolism, and thymulin activity, are reviewed.
Journal ArticleDOI
Formation and volatilisation of alkyl-iodides and -selenides in macrotidal estuaries
TL;DR: In this article, the occurrence of alkylated volatile iodide andselenide species was evidenced and investigatedin water, sediments and overlying atmosphere of three major European estuaries, such as the Gironde (F), the Rhine (NL), and the Scheldt(B/NL), along with the salinity gradient.
Book
Biochemistry of Halogenated Organic Compounds
TL;DR: A review of the literature on halogenated organic compounds can be found in this article, with a focus on the development of halogenation as medicinal agents and pharmacological tools and the fascinating biochemi cal processes that have been discovered and studied using these analogues.
Journal ArticleDOI
Epochal trace elements and evolution.
TL;DR: Boron, iodine and zinc can be termed epochal trace elements and inquiry should be directed towards the possible roles of other trace elements, which may have been epochal in evolution.
References
More filters
Journal ArticleDOI
Thyroid hormone action at the cellular level
TL;DR: In a given tissue, alterations in the total number of receptor sites has not been shown to be useful as an index of thyroid hormone response, and local modulation of the response to the triiodothyronine receptor complex by a variety of factors other than triiod Timothyronine may be carried out at a postreceptor level.
Journal ArticleDOI
The identification of 3:5:3'-l-triiodothyronine in human plasma
Jack Gross,Rosalind Pitt-Rivers +1 more
Journal ArticleDOI
Binding of selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei. High correlation between structural requirements for nuclear binding and biological activity.
TL;DR: The limited capacity, high affinity binding of 35 iodothyronine analogues by rat liver nuclei has been examined in an in vitro system and the data provide information on the structural requirements for thyroid hormone action and further support the physiological relevance of the nuclear sites.
Journal ArticleDOI
Thyroid hormone interactions: molecular conformation, protein binding, and hormone action.
TL;DR: It is shown that the thyroid hormones have profound effects on growth, differentiation, and development of tissues, as well as effects on carbohydrates, proteins, and lipids, and their molecular level interactions with these proteins are of paramount interest.
Journal ArticleDOI
Binding of thyroxine and triiodothyronine by nuclei of isolated tadpole liver cells.
TL;DR: Scatchard analyses suggest high affinity, saturable binding sites for both hormones in the nuclear but not in the cytoplasmic fraction.