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Journal ArticleDOI

Is the recommended daily allowance for vitamin D too low for the homebound elderly

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TLDR
It is concluded that the current RDA seems inadequate for many older individuals who do not get sun exposure and this particular population of elderly is at risk to develop vitamin D deficiency and the associated complications.
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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

TL;DR: Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmol/L (approximately 30 ng/mL) not only is important for maximizing intestinal calcium absorption but also may be important for providing the extrarenal 1alpha-hydroxylase that is present in most tissues to produce 1,25-dihydroxyv vitamin D3.
Journal ArticleDOI

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

TL;DR: The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.
Journal ArticleDOI

Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implications for Establishing a New Effective Dietary Intake Recommendation for Vitamin D

TL;DR: It has been more than 3 decades since the first assay assessing circulating 25-hydroxyvitamin D in human subjects was performed and led to the definition of "normal" nutritional vitamin D status, i.e., vitamin D sufficiency, and current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.
Journal ArticleDOI

Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level

TL;DR: The 100-microg/d dosage of vitamin D3 effectively increased 25( OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, 100 microg vitamin D 3/d is considered to be a safe intake.
Journal ArticleDOI

Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health

TL;DR: Vitamin D receptors are common in most tissues in the body, and the new revelation that many tissues produce 1,25-dihydroxyvitamin D suggests a new important role for this hormone in helping to maintain good health throughout life.
References
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Journal ArticleDOI

Vitamin D and bone health in the elderly

TL;DR: Vitamin D administration may raise plasma cholesterol but there is no convincing evidence that the risk of myocardial infarction is increased, and the recommended total supply for the elderly of 20 micrograms/day is most unlikely to be harmful, except in patients with sarcoidosis or renal calculi.
Journal ArticleDOI

The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects

TL;DR: It is concluded that a vitamin D3 supplement of 400 IU/day adequately improves vitamin D status in elderly people and increases 1,25-dihydroxyvitamin D concentrations in those with vitamin D deficiency.
Journal ArticleDOI

Nutritional status in a healthy elderly population: vitamin D

TL;DR: It is suggested that American elderly consider using a combination of moderate vitamin D supplementation and increased sunlight exposure in order to improve their vitamin D nutriture.
Journal ArticleDOI

Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure.

B W Hollis
- 01 Nov 1986 - 
TL;DR: This procedure offers the advantage of a single rapid purification step not involving "high-performance" liquid chromatography or evaporation, under nitrogen, of polar solvents such as acetonitrile or methanol.
Journal ArticleDOI

Nutritional status in a healthy elderly population: dietary and supplemental intakes.

TL;DR: Dietary and supplemental intakes were assessed from 3-day food records collected from 270 free-living, middle income and healthy men and women over 60 yr of age residing in the Albuquerque, NM vicinity and the 1980 Recommended Dietary Allowances were used to assess adequacy of intake.
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