Journal ArticleDOI
Is the recommended daily allowance for vitamin D too low for the homebound elderly
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It is concluded that the current RDA seems inadequate for many older individuals who do not get sun exposure and this particular population of elderly is at risk to develop vitamin D deficiency and the associated complications.Abstract:
A population of sunlight-deprived elderly was studied to determine the daily intake of vitamin D and whether dietary intake was sufficient to maintain a normal vitamin D status. Twenty-two subjects over 65 years old with serum creatinine less than 180 mumols/L and confined indoors for more than 6 months were chosen from the community and a nursing home in Southeast Baltimore. Three-day food records were obtained along with serum levels of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2 D), and intact parathyroid hormone (PTH). The mean daily vitamin D intake was over twofold greater than the adult Recommended Daily Allowance (RDA) of 200 IU. The mean 25-OHD level was 40 nmol/L (normal 25-138 nmol/L) with seven patients less than 25 nmol/L. Of these participants with 25-OHD values less than 25 nmol/L, the mean vitamin D intake was 467 IU (range 36-1096 IU). We conclude that the current RDA seems inadequate for many older individuals who do not get sun exposure. This particular population of elderly is at risk to develop vitamin D deficiency and the associated complications.read more
Citations
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Journal ArticleDOI
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
TL;DR: Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmol/L (approximately 30 ng/mL) not only is important for maximizing intestinal calcium absorption but also may be important for providing the extrarenal 1alpha-hydroxylase that is present in most tissues to produce 1,25-dihydroxyv vitamin D3.
Journal ArticleDOI
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
TL;DR: The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.
Journal ArticleDOI
Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implications for Establishing a New Effective Dietary Intake Recommendation for Vitamin D
TL;DR: It has been more than 3 decades since the first assay assessing circulating 25-hydroxyvitamin D in human subjects was performed and led to the definition of "normal" nutritional vitamin D status, i.e., vitamin D sufficiency, and current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.
Journal ArticleDOI
Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level
TL;DR: The 100-microg/d dosage of vitamin D3 effectively increased 25( OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, 100 microg vitamin D 3/d is considered to be a safe intake.
Journal ArticleDOI
Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health
TL;DR: Vitamin D receptors are common in most tissues in the body, and the new revelation that many tissues produce 1,25-dihydroxyvitamin D suggests a new important role for this hormone in helping to maintain good health throughout life.
References
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Journal ArticleDOI
Vitamin D and bone health in the elderly
TL;DR: Vitamin D administration may raise plasma cholesterol but there is no convincing evidence that the risk of myocardial infarction is increased, and the recommended total supply for the elderly of 20 micrograms/day is most unlikely to be harmful, except in patients with sarcoidosis or renal calculi.
Journal ArticleDOI
The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects
Paul Lips,A. Wiersinga,F.C. van Ginkel,M. J. M. Jongen,J. C. Netelenbos,Wil H.L. Hackeng,Pierre D. Delmas,W.J.F. van der Vijgh +7 more
TL;DR: It is concluded that a vitamin D3 supplement of 400 IU/day adequately improves vitamin D status in elderly people and increases 1,25-dihydroxyvitamin D concentrations in those with vitamin D deficiency.
Journal ArticleDOI
Nutritional status in a healthy elderly population: vitamin D
TL;DR: It is suggested that American elderly consider using a combination of moderate vitamin D supplementation and increased sunlight exposure in order to improve their vitamin D nutriture.
Journal ArticleDOI
Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure.
TL;DR: This procedure offers the advantage of a single rapid purification step not involving "high-performance" liquid chromatography or evaporation, under nitrogen, of polar solvents such as acetonitrile or methanol.
Journal ArticleDOI
Nutritional status in a healthy elderly population: dietary and supplemental intakes.
TL;DR: Dietary and supplemental intakes were assessed from 3-day food records collected from 270 free-living, middle income and healthy men and women over 60 yr of age residing in the Albuquerque, NM vicinity and the 1980 Recommended Dietary Allowances were used to assess adequacy of intake.
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