Joint Effects of Low Body Mass Index and Alcohol Consumption on Developing Esophageal Squamous Cell Cancer: a Korean Nationwide Population-Based Cohort Study
Yoon Jin Choi,Dong Ho Lee,Dong Ho Lee,Kyungdo Han,Hyuk Yoon,Cheol Min Shin,Young Soo Park,Young Soo Park,Nayoung Kim,Nayoung Kim +9 more
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TLDR
It was determined that underweight and obesity-compared with normal weight-were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively, and achieving normal range of BMI could reduce the risk of ESCC.Abstract:
Objective: In Korea, 95% of esophageal cancer (EC) was the squamous cell-type. We sought to determine the combined risk of alcohol consumption on developing esophageal squamous cell carcinoma (ESCC) in pre-diagnostic underweight subjects using Korean national data. Methods: We analyzed the clinical data from a total of 264,084 individuals aged 40 years or older, who received healthcare checkups arranged by the national insurance program, between 2003 and 2008 in Korea. Cox proportional hazards regression was used after adjusting confounding factors. Result: Newly diagnosed 278 EC was identified using the claims data during a median follow-up duration of 7.9 years. It was determined that underweight and obesity-compared with normal weight-were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively. Weight gain reduced the risk of EC. Alcohol consumption increased risk for EC in a dose-dependent manner. Heavy alcohol consumption in individuals with underweight increased the risk of developing EC dramatically. Conclusion: Underweight was a risk factor for ESCC and alcohol consumption raised the risk synergistically with low BMI. Achieving normal range of BMI could reduce the risk of ESCC.read more
Citations
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Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea
TL;DR: Increasing abdominal obesity may be associated with an increased risk for esophageal cancer, and further studies are warranted to confirm the relationship.
Journal ArticleDOI
Cumulative evidence for the relationship between body mass index and the risk of esophageal cancer: An updated meta-analysis with evidence from 25 observational studies.
TL;DR: A large number of papers reporting the relationships between body mass index (BMI) and esophageal cancer risk have been published in the past few decades; however, these results are inconsistent.
Journal ArticleDOI
Clinical significance of tumor necrosis factor receptor 2 in middle and lower thoracic esophageal squamous cell carcinoma.
TL;DR: The results suggest that TNFR2 can play an important role in the progression and poor prognosis of ESCC patients, and the role ofTNFR2 in the prog outlook of middle thoracic ES CC patients was earlier and stronger than in lower thoraco-ESCC patients.
Journal ArticleDOI
Adult height, body mass index change, and body shape change in relation to esophageal squamous cell carcinoma risk: A population-based case-control study in China.
Xiaorong Yang,Tongchao Zhang,Xiaolin Yin,Ziyu Yuan,Hui Chen,Amelie Plymoth,Li Jin,Xingdong Chen,Ming Lu,Ming Lu,Weimin Ye,Weimin Ye +11 more
TL;DR: Maintaining a fit body shape and a reasonable BMI is advisable and of vital importance to reduce the risk of esophageal squamous cell carcinoma, especially in high‐risk areas.
Book
Esophageal squamous cell carcinoma : diagnosis and treatment
TL;DR: 1. Epidemiology of ESCC, Pathology of Esophageal Squamous Cell Carcinoma, and Endoscopic diagnosis: Endoscopic treatment: EMR and ESD.
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