Open AccessJournal Article
Lack of keratan sulphate in the human notochord.
TLDR
The contribution made by notochordal-derived keratan sulphate to the glycosaminoglycan content of the mature intervertebral disc may differ in man from that of other animal species.Abstract:
Intervertebral discs, formed from notochord cell expansions during embryogenesis, are known to contain proteoglycans bearing keratan sulphate chains. Keratan sulphate has previously been demonstrated in Xenopus and chick notochords and in human fetal cartilage. In contrast, we have been unable to demonstrate keratan sulphate in human fetal notochord using two monoclonal antibodies, MZ15 and 5-D-4. The contribution made by notochordal-derived keratan sulphate to the glycosaminoglycan content of the mature intervertebral disc may differ in man from that of other animal species.read more
Citations
More filters
Journal ArticleDOI
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix.
TL;DR: Current research is aimed at trying to restore the integrity of the degenerate disc matrix by biologic means, although at present it is not clear what the structure of the most appropriate repair tissue should be or how it can be achieved.
Journal ArticleDOI
Development and involution of the notochord in the human spine.
TL;DR: Results of this histological, histochemical and immunohistochemical study are in accord with the dominant view in the literature that the notochord does not contribute materially to the adult nucleus pulposus.
Journal ArticleDOI
Evolutionary conservation of mechanisms upstream of asymmetric Nodal expression: reconciling chick and Xenopus
Michael Levin,Mark Mercola +1 more
TL;DR: This work shows that in the chick, as in the frog, explanted mesoderm from both sides does, indeed, go on to express nodal, including both the medial and lateral expression domains, and proposes a single conserved mechanism upstream of nodal expression.
Journal ArticleDOI
Yin Yang 1, a vertebrate polycomb group gene, regulates antero-posterior neural patterning.
Hye-Joo Kwon,Hae-Moon Chung +1 more
TL;DR: Results suggest that YY1 controls antero-posterior patterning of the CNS during Xenopus embryonic development, and is required for the stable repression of the homeotic genes and other developmentally regulated genes.