Journal ArticleDOI
Identification of a developmentally regulated keratan sulfate proteoglycan that inhibits cell adhesion and neurite outgrowth
Gregory J. Cole,Craig F. McCabe +1 more
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Data suggest that this neural keratan sulfate proteoglycan plays an important role in the modulation of neuronal cell adhesion during embryonic brain development.About:
This article is published in Neuron.The article was published on 1991-12-01. It has received 167 citations till now. The article focuses on the topics: Aggrecan & Perlecan.read more
Citations
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Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
Journal ArticleDOI
Regulation of development and differentiation by the extracellular matrix
Josephine C. Adams,Fiona M. Watt +1 more
TL;DR: Some of the evidence that ECM components regulate differentiation and development are summarized, the regulatory mechanisms involved are described and the intracellular events that may transduce signals are discussed.
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Functional regeneration beyond the glial scar.
Jared M. Cregg,Marc A. DePaul,Angela R. Filous,Bradley T. Lang,Amanda Phuong Tran,Jerry Silver +5 more
TL;DR: Evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury is reviewed and several exciting new interventions that allow axons to regenerate beyond the glial scar are considered.
Patent
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
TL;DR: In this paper, a soluble neutral active hyaluronidase glycoprotein (sHASEGP) was proposed to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies.
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Chondroitin sulfate as a regulator of neuronal patterning in the retina
TL;DR: In the developing mammalian retina, gradual regression of chondroitin sulfate may help control the onset of ganglion cell differentiation and initial direction of their axons.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.
P Caroni,Martin E. Schwab +1 more
TL;DR: The data presented demonstrate the existence of membrane proteins with potent nonpermissive substrate properties and suggest that these proteins might play a crucial inhibitory role during development and regeneration in CNS white matter.
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Formation of anhydrosugars in the chemical depolymerization of heparin.
John E. Shively,H. Edward Conrad +1 more
TL;DR: It is demonstrated here that only low pH reaction conditions favor the deamination of N-sulfated D-glucosamine residues; the reaction proceeds very slowly at pH 3.5 or above and at room temperature solutions of nitrous acid lose one-fourth to one-third of their capacity to deaminate amino sugars in 1 h at all pHs.
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Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
TL;DR: It is demonstrated that KS/CS-PG is inhibitory to embryonic dorsal root ganglia neurites in vitro and that complete inhibition requires contributions from both KS and CS moieties.