Journal ArticleDOI
Lead exposure and latent learning ability of adult female rats.
Ana Lúcia S. Rodrigues,Ana Lúcia S. Rodrigues,Maribel Antonello Rubin,Maribel Antonello Rubin,Diogo O. Souza,Diogo O. Souza,Carlos Fernando Mello +6 more
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TLDR
The results suggest that rats intoxicated with lead are able to learn about the environment when no immediate reinforcement is involved, and both lead-treated and control rats that had been previously exposure to the maze performed better than those exposed to the open field.About:
This article is published in Behavioral and Neural Biology.The article was published on 1993-11-01. It has received 12 citations till now. The article focuses on the topics: Lead acetate & Latent learning.read more
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Effect of Perinatal Lead Exposure on Rat Behaviour in Open-Field and Two-Wky Avoidance Tasks
TL;DR: In this paper, the authors investigated behavior in the open field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats and found that lead exposure associated with behavioural alterations.
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Effect of treatment with mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on δ-aminolevulinic acid dehydratase (ALA-D) activity in brain, liver, kidney and blood of suckling rats
TL;DR: The enzyme was more affected by mercury than by lead in vivo, while in vitro lead was more potent that mercury as an ALA-D inhibitor.
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Lead (Pb+2) impairs long-term memory and blocks learning-induced increases in hippocampal protein kinase C activity
TL;DR: The results indicate that Pb( +2) causes cognitive impairments in adult rats and that such effects might be subserved by interference with Ca(+2)-related signaling mechanisms required for normal LTM.
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Effect of mercuric chloride and lead acetate treatment during the second stage of rapid post-natal brain growth on the behavioral response to chlorpromazine and on δ-ALA-D activity in weaning rats
TL;DR: It is suggested that a short exposure to lead or mercury during suckling caused permanent changes in locomotor activity that can be interpreted as hyperactivity in animals exposed to lead for long periods.
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Neural and behavioral teratological evaluation of rats exposed to ultra-wideband electromagnetic fields.
Brenda L. Cobb,James R. Jauchem,Patrick A. Mason,Michael Patrick Dooley,Stephanie A. Miller,John M. Ziriax,Michael R. Murphy +6 more
TL;DR: There does not appear to be a unifying physiological or behavioral relationship among the significant differences observed, and the findings could be due to the expected spurious results derived when a large number of statistical comparisons are made.
References
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The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report.
TL;DR: Exposure to lead in childhood is associated with deficits in central nervous system functioning that persist into young adulthood, and lead levels were inversely related to self-reports of minor delinquent activity.
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Port Pirie Cohort Study: environmental exposure to lead and children's abilities at the age of four years.
Anthony J. McMichael,Peter A. Baghurst,Neil R. Wigg,Graham V. Vimpani,Evelyn F. Robertson,Russell Roberts +5 more
TL;DR: It is concluded that postnatal blood lead concentration is inversely related to cognitive development in children, although one must be circumspect in making causal inferences from studies of this relation, because of the difficulties in defining and controlling confounding effects.
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Mechanisms of lead neurotoxicity.
TL;DR: Brain homeostatic mechanisms are disrupted by exposure to higher levels of lead, and the final pathway appears to be a breakdown in the blood-brain barrier.
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The long-term effects of exposure to low doses of lead in childhood
Michael I. Good,Claire B. Ernhart,Tom Greene,Thomas A. Boyd,Marion R. Sills,Kathryn R. Mahaffey,Ellen K. Silbergeld,Herbert L. Needleman +7 more
TL;DR: To determine whether the effects of low-level lead exposure persist, reexamined 132 of 270 young adults who had initially been studied as primary schoolchildren in 1975 through 1978, finding impairment in neurobehavioral function was still found to be related to the lead content of teeth shed at the ages of six and seven.
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Hyperactivity and brain catecholamines in lead-exposed developing rats.
TL;DR: Newborn rats that suckled mothers eating a diet containing 4 percent lead carbonate display hyperactivity, aggressiveness, and excessive stereotyped behavior starting at 4 weeks of age, which suggests a relationship between central nervous system dysfunction due to lead and dopamine metabolism in brain.