Journal ArticleDOI
Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to D-amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens.
Hervé Simon,Khalid Taghzouti,H. Gozlan,J. M. Studler,Alain Louilot,Denis Hervé,Jacques Glowinski,Jean-Pol Tassin,M. Le Moal +8 more
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TLDR
By post-mortem biochemical measurements, it is shown that bilateral 6-OHDA lesions of DA innervation of the amygdala leads to an increase in DA activity in the nucleus accumbens and a reduction in the prefrontal cortex.About:
This article is published in Brain Research.The article was published on 1988-05-03. It has received 131 citations till now. The article focuses on the topics: Nucleus accumbens & Dopaminergic.read more
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The neuropsychology of schizophrenia.
TL;DR: A model is proposed for integrating the neural and cognitive aspects of the positive symptoms of acute schizophrenia, using evidence from postmortem neuropathology and neurochemistry, clinical and preclinical studies of dopaminergic neurotransmission, anatomical connections between the limbic system and basal ganglia, attentional and other cognitive abnormalities underlying the positive Symptoms of schizophrenia.
Journal ArticleDOI
The neuropsychological basis of addictive behaviour.
TL;DR: The argument advanced in this review is that drug addiction can be understood in terms of normal learning and memory systems of the brain which, through the actions of chronically self-administered drugs, are pathologically subverted, leading to the establishment of compulsive drug-seeking habits, strengthened by the motivational impact of drug-associated stimuli and occurring at the expense of other sources of reinforcement.
Book
The Amygdala: a functional analysis
TL;DR: Functional neuroimaging of the amygdala during emotional processing and learning shows the importance of fibres of passage from the basal forebrain in the memory of reward.
Journal ArticleDOI
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
Barry J. Everitt,John A. Parkinson,Mary C. Olmstead,Mercedes Arroyo,Patricia Robledo,Trevor W. Robbins +5 more
TL;DR: Understanding of the special role of the ventral striatum is enriched in coordinating the contribution of different functional subsystems to confer flexibility, as well as coherence and vigor, to goal‐directed behavior, through different forms of associative learning.
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Triadic model of the neurobiology of motivated behavior in adolescence
TL;DR: In this article, a triadic, neuroscience systems-based model of adolescent decision-making is presented, where the functional role and neurodevelopmental findings of three key structures in the control of motivated behavior, i.e. amygdala, nucleus accumbens, and medial/ventral prefrontal cortex are reviewed.
References
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Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum.
TL;DR: Recovery of behavioural effects correlated with an increase in the remaining levels of DA in the NAS, and there is evidence that remaining DA levels in theNAS are greater at 90 than at 14 days postoperatively.
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Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
J. E. Krettek,Joseph L. Price +1 more
TL;DR: The efferent fiber connections of the nuclei of the amygdaloid complex with subcortical structures in the basal telencephalon, hypothalamus, midbrain, and pons have been studied in the rat and cat, using the autoradiographic method for tracing axonal connections.
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The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods
TL;DR: Findings in additional autoradiographic material identify this relatively non-limbic striatal quadrant as the main region of distribution of the corticostriatal projection from the sensorimotor cortex.
Journal ArticleDOI
Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat.
TL;DR: Using the retrograde transport of horseradish peroxidase, projections to the ventral tegmental area of Tsai (VTA) and related dopaminergic cell groups are made and regions of the brain labelled by VTA injections are assessed in relation to control injections and the limitations of the HRP technique.
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Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia
TL;DR: In this article, it was found that a specific increase of dopamine is found in the amygdalae in the left cerebral hemisphere of the schizophrenic group, which is inconsistent with the major neurochemical hypothesis of schizophrenia, which proposes an increase in dopamine neurotransmission which can be blocked by neuroleptic drugs.
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Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum.
The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study
A.E. Kelley,Valerie B. Domesick +1 more