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Linear mixed-effects models using R
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The article was published on 2013-01-01. It has received 432 citations till now. The article focuses on the topics: Computer network programming & Abstract machine.read more
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SIMR: an R package for power analysis of generalized linear mixed models by simulation
Peter Green,Catriona J. MacLeod +1 more
TL;DR: This paper presents a tutorial using a simple example of count data with mixed effects to guide the user along a gentle learning curve, adding only a few commands or options at a time.
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Parsimonious Mixed Models
TL;DR: This work shows that failure to converge typically is not due to a suboptimal estimation algorithm, but is a consequence of attempting to fit a model that is too complex to be properly supported by the data, irrespective of whether estimation is based on maximum likelihood or on Bayesian hierarchical modeling with uninformative or weakly informative priors.
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Physiological plasticity increases resilience of ectothermic animals to climate change
TL;DR: Research synthesizing the current state of knowledge about physiological plasticity in ectotherms shows that freshwater and marine animals seem to have a greater capacity for acclimation than terrestrial ones.
Journal ArticleDOI
An International Ki67 Reproducibility Study
Mei Yin C. Polley,Samuel C Y Leung,Lisa M. McShane,Dongxia Gao,Judith Hugh,Mauro G. Mastropasqua,Giuseppe Viale,Lila Zabaglo,Frédérique Penault-Llorca,John M. S. Bartlett,Allen M. Gown,W. Fraser Symmans,Tammy Piper,Erika Mehl,Rebecca A. Enos,Daniel F. Hayes,Mitch Dowsett,Torsten O. Nielsen +17 more
TL;DR: Substantial variability in Ki67 scoring was observed among some of the world's most experienced laboratories, and factors contributing to interlaboratory discordance included tumor region selection, counting method, and subjective assessment of staining positivity.
Journal ArticleDOI
Ocean acidification causes ecosystem shifts via altered competitive interactions
TL;DR: Although calcareous species recruited and grew at similar rates to fleshy seaweeds in ambient and low pH conditions, at later stages in low pH, they were rapidly overgrown, suggesting that changes in competitive balance could indirectly lead to profound ecosystem changes in an acidified ocean.