Journal ArticleDOI
Lithium in the treatment of depression.
TLDR
There is convincing, although not conclusive, evidence for an antidepressant effect of lithium and that only by identifying the subgroup of patients for whom it is effective can the continuing uncertainty surrounding lithium's role in affective disorder be resolved.Abstract:
The author reviews the studies of lithium as an antidepressant, evaluates the evidence that there might be specific subgroup of patients for whom it is effective, and reports a study he and his associates conducted that found lithium to be effective for 13 of 21 depressed patients. He concludes that there is convincing, although not conclusive, evidence for an antidepressant effect of lithium and that only by identifying the subgroup of patients for whom it is effective can the continuing uncertainty surrounding lithium's role in affective disorder be resolved. He also calls for a reevaluation of the relationship between mania and depression.read more
Citations
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Journal ArticleDOI
Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders.
Hagop S. Akiskal,Marc Bourgeois,Jules Angst,Robert M. Post,Hans-Jürgen Möller,Robert M. A. Hirschfeld +5 more
TL;DR: The present review did not consider cyclic, seasonal, irritable-dysphoric or otherwise impulse-ridden, intermittently explosive or agitated psychiatric conditions for which the bipolar connection is less established.
Journal ArticleDOI
What Is a “Mood Stabilizer”? An Evidence-Based Response
Mark S. Bauer,Landis Mitchner +1 more
TL;DR: The evidence supported a role for lithium as first-line agent for treatment of bipolar disorder when all four treatment roles are considered and highlights unmet needs and promising agents and provides a yardstick for evaluating new treatment strategies.
Journal ArticleDOI
The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV.
TL;DR: The existence of a broad bipolar spectrum between the extremes of psychotic manic-depressive illness and strictly defined unipolar depression is reaffirmed.
Journal ArticleDOI
Antidepressants in bipolar disorder: the case for caution.
TL;DR: There is a strong rationale for a cautious approach to antidepressant use in bipolar disorder, consistent with, and perhaps even more strongly than, the APA guidelines, according to an interpretation of the evidence.
Journal ArticleDOI
Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders.
TL;DR: This rapid antidepressant effect of lithium in "treatment-resistant' patients might be due to the enhancement of the efficacy of the central serotoninergic system, unveiling the tricyclic antidepressant-induced sensitization of the serotoninergic postsynaptic receptors.
References
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Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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Lithium salts in the treatment of psychotic excitement.
TL;DR: The Medical Journal of Australia as discussed by the authors republish Cade's seminal paper and acknowledge their debt to The Medical Journal for allowing us to reprint the article from their September 1949 issue.
Journal ArticleDOI
The treatment of depressive states with g 22355 (imipramine hydrochloride)
TL;DR: It was demonstrated that the compound has potent antidepressant action and best responses were obtained in cases of endogenous depression showing the typical symptoms of mental and motor retardation, fatigue, feeling of heaviness, hopelessness, guilt, and despair.
Journal ArticleDOI
Lithium in psychiatric therapy and prophylaxis.
TL;DR: An up-to-date, critical assessment of psychiatric lithium therapy and prophylactic action against endogenous affective disorder, including manic-depressive disorder and recurrent endogenous depressions is presented.
Journal ArticleDOI
Methods for Reliable Longitudinal Observation of Behavior: Development of a Method for Systematic Observation of Emotional Behavior on Psychiatric Wards
TL;DR: This article developed a method for the observation and recording on a psychiatric ward of behavioral data which could be correlated with biochemical measurements and used to follow the "natural history" of a mental illness on a continuous day-to-day basis.