Long-term anti-HBs antibody persistence following infant vaccination against hepatitis B and evaluation of anamnestic response A 20-year follow-up study in Thailand
Yong Poovorawan,Voranush Chongsrisawat,Apiradee Theamboonlers,Priya Diana Crasta,Marc Messier,Karin Hardt +5 more
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TLDR
Long-term immunogenicity of the 4-dose regimen of the HBV vaccine eliciting long-term persistence of antibodies and immune memory against hepatitis B for up to at least 20 y after vaccination is confirmed.Abstract:
Hepatitis B vaccine has been available worldwide since the mid-1980s. This vaccine was evaluated in a clinical trial in Thailand, conducted on subjects born to hepatitis B surface antigen positive and hepatitis B e-antigen positive mothers and vaccinated according to a 4-dose schedule at 0, 1, 2 and 12 mo of age and a single dose of hepatitis B immunoglobulin concomitantly at birth. All enrolled subjects seroconverted and were followed for 20 y to assess the persistence of antibody to the hepatitis B surface antigen (anti-HBs) (NCT00240539). At year 20, 64% of subjects had anti-HBs antibody concentrations≥10 milli-international units per milli liter (mIU/ml) and 92% of subjects had detectable levels (≥3.3 mIU/ml) of anti-HBs antibodies. At year 20, subjects with anti-HBs antibody titer<100 mIU/ml were offered an additional dose of hepatitis B virus (HBV) vaccine to assess immune memory (NCT00657657). Anamnestic response to the challenge dose was observed in 96.6% of subjects with an 82-fold (13.2 to 1082.4 mIU/ml) increase in anti-HBs antibody geometric mean concentrations. This study confirms the long-term immunogenicity of the 4-dose regimen of the HBV vaccine eliciting long-term persistence of antibodies and immune memory against hepatitis B for up to at least 20 y after vaccination.read more
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Journal ArticleDOI
Prevention of Perinatal Hepatitis B Virus Transmission
TL;DR: Screening pregnant women for HBV infection, providing infant postexposure prophylaxis, and maternal treatment with antiviral medications are strategies for reducing MTCT transmission rates and the global burden of new chronic HBV infections.
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The Success of a Universal Hepatitis B Immunization Program as Part of Thailand's EPI after 22 Years' Implementation.
Nawarat Posuwan,Nasamon Wanlapakorn,Pattaratida Sa-nguanmoo,Rujipat Wasitthankasem,Preeyaporn Vichaiwattana,Sirapa Klinfueng,Viboonsak Vuthitanachot,Siriporn Saelao,Monthana Foonoi,Apinya Fakthongyoo,Jamorn Makaroon,Klaita Srisingh,Duangporn Asawarachun,Somchai Owatanapanich,Norra Wutthiratkowit,Kraisorn Tohtubtiang,Pornsak Yoocharoen,Sompong Vongpunsawad,Yong Poovorawan +18 more
TL;DR: The number of HB virus (HBV) carriers, both children and young adults, who were born after universal HB vaccination was markedly reduced, and HBV infection by means of detectable anti-HBc had also drastically declined in the population born after the HB vaccine was integrated into the EPI program.
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Hepatitis B Vaccines.
John W. Ward,Pierre Van Damme +1 more
TL;DR: The hepatitis B vaccines have an overall efficacy of 80-100% and provide virtually complete protection against acute and chronic hepatitis B infection among persons who complete the three-dose vaccination series as mentioned in this paper.
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Vaccination in HIV-infected adults
TL;DR: A review of the current recommendations regarding vaccines among HIV-infected adults and a comprehensive summary of the evidence-based literature of the benefits and risks of vaccines among this vulnerable population are provided.
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Biosensing strategies for the electrochemical detection of viruses and viral diseases - A review.
Laís Canniatti Brazaca,Pãmyla L. dos Santos,Paulo Roberto de Oliveira,Diego P. Rocha,Jéssica S. Stefano,Cristiane Kalinke,Rodrigo A.A. Munoz,Juliano Alves Bonacin,Bruno C. Janegitz,Emanuel Carrilho +9 more
TL;DR: In this article, a review article describes the advancements achieved in the last five years regarding electrochemical biosensors for the diagnosis of viral infections, as well as point of care systems and their advantages when compared to traditional techniques.
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