Journal ArticleDOI
Long-term outcome associated with intratumoral chemotherapy with cisplatin for cutaneous tumors in equidae: 573 cases (1995-2004).
Alain P Theon,W. David Wilson,K. Gary Magdesian,Nicola Pusterla,Jack R. Snyder,Larry D. Galuppo +5 more
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The value of intratumoral chemotherapy with cisplatin for treatment of cutaneous tumors in equidae was confirmed and the results cannot be extrapolated to other formulations of cisPlatin or other protocols that might be used.Abstract:
Objective—To determine outcome associated with cutaneous tumors treated via intratumoral chemotherapy with cisplatin and identify risk factors affecting local tumor control and complications in equidae. Design—Retrospective case series. Animals—573 equidae with 630 cutaneous tumors. Procedures—Medical records of horses, mules, donkeys, and ponies with cutaneous tumors treated via intratumoral chemotherapy with cisplatin were analyzed. Results—549 horses, 13 mules, 8 donkeys, and 3 ponies with 630 histologically confirmed cutaneous tumors were included. Tumors included sarcoids (n = 409), squamous cell carci nomas (151), soft tissue sarcomas (28), cutaneous lymphomas (26), and melanomas (16). Overall cure rate, defined as local control at 4 years, was 93.3%. For all tumor stages combined, cure rates after 1 course of treatment were 96.3% for sarcoids, 96% for lym-phomas, 88% for squamous cell carcinomas, 85% for soft tissue sarcomas, and 81% for melanomas. Treatment protocol, tumor stage, and prior treatme...read more
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Journal ArticleDOI
Electrochemotherapy in Veterinary Oncology
Maja Cemazar,Y. Tamzali,Gregor Sersa,N. Tozon,Lluis M. Mir,Damijan Miklavčič,R. Lowe,Justin Teissié +7 more
TL;DR: Electrochemotherapy in veterinary oncology has future promise to be highly effective, and could be used to treat primary or recurrent solitary or multiple cutaneous and SC tumors of different histology or as an adjuvant treatment to surgery.
Journal ArticleDOI
Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases.
TL;DR: It is demonstrated that ECT, with or without concurrent tumour debulking, is an effective alternative for treatment of equine sarcoids.
Journal ArticleDOI
A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research.
Dorian M. Cheff,Matthew D. Hall +1 more
TL;DR: The current Pt drug landscape and challenges for future Pt development are assessed and opportunities for improving the understanding of Pt drugs that utilize contemporary translational science tools such as chemical biology and real-time imaging are discussed.
Journal ArticleDOI
Equine melanocytic tumors.
TL;DR: An understanding of the specific molecular genetic factors associated with tumor formation should lead to targeted therapies that can be used to treat or ideally prevent disease.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
BookDOI
Cisplatin : chemistry and biochemistry of a leading anticancer drug
TL;DR: The start: platinum complexes for the treatment of cancer - why the search goes on and new developments: structure-activity relationships within di- and trinuclear platinum phase I clinical anticancer agents the development of orally-active platinum drugs methods for screening the potential antitumor activity of platinum compounds in combinatorial libraries computational studies on platinum antitumors complexes and their adducts with nucleid acids constituents.
Journal ArticleDOI
Regression Models in Clinical Studies: Determining Relationships Between Predictors and Response
TL;DR: This paper addresses the latter assumption of the distribution of the response variable by applying a direct and flexible approach, cubic spline functions, to two widely used models: the logistic regression model for binary responses and the Cox proportional hazards regression models for survival time data.
Book
Current Therapy in Equine Medicine 2
TL;DR: This volume of the standard reference presents a unique version of modern therapy in equine medicine, which discusses both common and unusual diseases of the horse, including alimentary tract, cardiovascular, foal, respiratory, skin, and more.
Journal ArticleDOI
Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.
Lluis M. Mir,Glass Lf,Gregor Sersa,Justin Teissié,Christian Domenge,Damijan Miklavčič,Mark J. Jaroszeski,Stéphane Orlowski,Douglas S. Reintgen,Z Rudolf,M. Belehradek,Richard Gilbert,Marie-Pierre Rols,J. Belehradek,Jean-Marc Bachaud,Ronald C. DeConti,Borut Štabuc,Maja Cemazar,P Coninx,Richard Heller +19 more
TL;DR: ECT was shown to be an effective local treatment and was effective regardless of the histological type of the tumour, and offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate.
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