Journal ArticleDOI
Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women.
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TLDR
These results are the first to prospectively evaluate the longitudinal changes in maternal carbohydrate metabolism from the time before conception through late gestation with newer methods such as the hyperinsulinemic-euglycemic clamp.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1991-12-01. It has received 616 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
Citations
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Weight Gain During Pregnancy: Reexamining the Guidelines
TL;DR: The IOM's Food and Nutrition Board and the Division of Behavioral and Social Sciences and Education Board on Children, Youth, and Families as mentioned in this paper reviewed and updated the IOM (1990) recommendations for weight gain during pregnancy and recommend ways to encourage their adoption through consumer education, strategies to assist practitioners, and public health strategies.
Journal ArticleDOI
Gestational Diabetes Mellitus
Thomas A. Buchanan,Anny H. Xiang +1 more
TL;DR: Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees that is first detected during pregnancy and provides a unique opportunity to study the early pathogenesis of diabetes and to develop interventions to prevent the disease.
Journal ArticleDOI
Genetic conflicts in human pregnancy.
TL;DR: The placenta is able to release hormones and other substances directly into the maternal circulation as discussed by the authors, which can be interpreted as an attempt by a poorly nourished fetus to increase its supply of nutrients by increasing the resistance of its mother's peripheral circulation.
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The Pathophysiology of Gestational Diabetes Mellitus
TL;DR: What is known about the pathophysiology of GDM, and where there are gaps in the literature that warrant further exploration are discussed, are discussed.
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Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus
TL;DR: Recent advances in carbohydrate metabolism during pregnancy suggest that preventive measures should be aimed at improving insulin sensitivity in women predisposed to GDM, and further research is needed to elucidate the mechanisms and consequences of alterations in lipid metabolism duringregnancy.
References
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Journal ArticleDOI
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
TL;DR: Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique] are described.
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Criteria for screening tests for gestational diabetes
TL;DR: Test results suggest that thresholds for further testing be lowered from 143 to 135 mg/dl of plasma glucose, where further testing is required.
Book
Methods of hormone radioimmunoassay.
TL;DR: This ebooks is under topic such as a radioimmunoassay method for human pituitary luteinizing methods inRadioimmunOassay, toxicology, and springer, and a rapid radioIMmunoASSay method of (39161) ultrafiltration method for direct radioim Muncoassay measurement new solid phases for estimation of hormones by agreement between electrochemiluminescence and raciloimmunosynthesis.
Journal ArticleDOI
Insulin action during pregnancy. Studies with the euglycemic clamp technique
TL;DR: These studies suggest that the insulin resistance of pregnancy results from a target cell defect in insulin action beyond the initial step of insulin binding to cellular receptors, a postreceptor (or postbinding) defect inulin action.