Proceedings ArticleDOI
Longitudinal performance of a vestibular prosthesis as assessed by electrically evoked compound action potential recording
James O. Phillips,Sarah J. Shepherd,Amy Nowack,Leo Ling,Steven M. Bierer,Chris R. S. Kaneko,Christopher M. Phillips,Kaibao Nie,Jay T. Rubinstein +8 more
- Vol. 2012, pp 6128-6131
TLDR
The results suggest that vECAPs, and therefore electrical activation of vestibular afferent fibers, can remain largely stable over time following implantation.Abstract:
Electrical stimulation of the vestibular end organ with a vestibular prosthesis may provide an effective treatment for vestibular loss if the stimulation remains effective over a significant period of time after implantation of the device. To assess efficacy of electrical stimulation in an animal model, we implanted 3 rhesus monkeys with a vestibular prosthesis based on a cochlear implant. We then recorded vestibular electrically evoked compound action potentials (vECAPs) longitudinally in each of the implanted canals to see how the amplitude of the response changed over time. The results suggest that vECAPs, and therefore electrical activation of vestibular afferent fibers, can remain largely stable over time following implantation.read more
Citations
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Journal ArticleDOI
Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects
James O. Phillips,Leo Ling,Kaibao Nie,Elyse Jameyson,Christopher M. Phillips,Amy Nowack,Justin S. Golub,Jay T. Rubinstein +7 more
TL;DR: It is demonstrated that canal-specific two-dimensionally (2D) measured eye velocities are elicited from intermittent brief 2 s biphasic pulse electrical stimulation in four human subjects implanted with a Vestibular prosthesis, suggesting that electrical stimulation of the vestibular end organ in human subjects provided controlled vestibul inputs over time.
Journal ArticleDOI
Postural responses to electrical stimulation of the vestibular end organs in human subjects.
Christopher A. Phillips,Christina DeFrancisci,Leo Ling,Kaibao Nie,Amy Nowack,James O. Phillips,Jay T. Rubinstein +6 more
TL;DR: It is demonstrated that electrical stimulation trains delivered to the perilymph of individual semicircular canals elicit postural responses specific to the particular canal stimulated, with some current spread to adjacent end organs.
Journal ArticleDOI
Development of a Multichannel Vestibular Prosthesis Prototype by Modification of a Commercially Available Cochlear Implant
TL;DR: Software and circuitry to sense head rotation and drive a CI's implanted stimulator (IS) to deliver up to 1 K pulses/s via nine electrodes implanted near vestibular nerve branches are developed.
Journal ArticleDOI
Longitudinal performance of an implantable vestibular prosthesis.
Christopher A. Phillips,Leo Ling,Trey Oxford,Amy Nowack,Kaibao Nie,Jay T. Rubinstein,James O. Phillips +6 more
TL;DR: In this paper, a large consecutive series of implanted rhesus macaque was studied longitudinally using brief stimuli designed to limit adaptive changes in response, so that the efficacy of electrical activation can be studied over time, across surgeries, canals and animals.
Journal ArticleDOI
A Vestibular Prosthesis With Highly-Isolated Parallel Multichannel Stimulation
TL;DR: An implantable vestibular stimulation system capable of providing high flexibility independent parallel stimulation to the semicircular canals in the inner ear for restoring three-dimensional sensation of head movements is presented.
References
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Journal ArticleDOI
Implantation of magnetic search coils for measurement of eye position: an improved method.
Journal ArticleDOI
System design and performance of a unilateral horizontal semicircular canal prosthesis
Wangsong Gong,Daniel M. Merfeld +1 more
TL;DR: The experiments show that the nervous system adapts to the artificial rotational cue provided via electrical stimulation, and also shows that the function of the canals was partially restored.
Journal ArticleDOI
Chronic Vestibulo-Ocular Reflexes Evoked by a Vestibular Prosthesis
TL;DR: A sensory-replacement prosthesis that stimulates neurons innervating the vestibular system by providing chronic pulsatile stimulation to electrodes placed in monkeys' lateral semicircular canals and used head angular velocity to modulate the current pulse rate suggests that long-term functional replacement of absent Vestibular function is feasible.
Journal ArticleDOI
Acclimation to Chronic Constant-Rate Peripheral Stimulation Provided by a Vestibular Prosthesis
TL;DR: Findings show that the brain acclimates to constant-rate stimulation, which is turned on only when necessary, for example, to override unnatural variations like those experienced by patients suffering from Meniere's syndrome.
Journal ArticleDOI
Eye movements in response to electrical stimulation of the lateral and superior ampullary nerves.
TL;DR: It is possible to stimulate electrically the lateral and superior ampullary nerves without simultaneous stimulation of the facial nerve and this site can be used to encode horizontal movements, because central adaptation may correct unnatural afferent vestibular cues delivered by a prosthetic sensor.