Low-grade gliomas in children: tumor volume response to radiation.
Barbara Fisher,Glenn Bauman,Christopher E. Leighton,Larry Stitt,J. Gregory Cairncross,David R. Macdonald +5 more
TLDR
In this article, the frequency, degree, and timing of radiologically confirmed response to radiotherapy of low-grade gliomas in children were examined and documented by comparing postoperative, pre-radiation computerized tomography (CT) scans with post-irradiation, follow-up CT scans.Abstract:
Object. The authors conducted a retrospective review to examine and document the frequency, degree, and timing of the radiologically confirmed response to radiotherapy of low-grade gliomas in children. Methods. Between 1963 and 1995, 80 patients 17 years of age or younger were referred to the London Regional Cancer Centre in London, Ontario after diagnosis of a low-grade glioma. All patients underwent surgical resection or biopsy procedures and 47 underwent radiotherapy (40 postoperatively and seven at the time of tumor progression). Nineteen patients with residual measurable lesions who received radiation therapy were selected for volumetric analysis of tumor response to this treatment. The extent and timing of response to radiation were determined by the process of comparing postoperative, preirradiation computerized tomography (CT) scans with postirradiation, follow-up CT scans. For one patient the comparison was made by using serial magnetic resonance images. Residual tumor was found on postoperative ...read more
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Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults
Shlomi Constantini,Douglas C. Miller,Jeffrey C. Allen,Lucy B. Rorke,Diana Freed,Fred Epstein +5 more
TL;DR: The long-term survival and quality of life for patients with low-grade gliomas treated by radical resection alone is comparable or superior to minimal resection and radiotherapy.
Journal ArticleDOI
Pediatric Low-Grade Gliomas
Angela J. Sievert,Michael Fisher +1 more
TL;DR: Pediatric low-grade gliomas encompass a heterogeneous set of tumors of different histologies and have minimal potential for resection; these tumors can be difficult to treat and deserve special attention.
Journal ArticleDOI
Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases: Clinical article
Giannina L. Garcés-Ambrossi,Matthew J. McGirt,Vivek A. Mehta,Daniel M. Sciubba,Timothy F. Witham,Ali Bydon,Jean Paul Wolinksy,George I. Jallo,Ziya L. Gokaslan +8 more
TL;DR: Gross-total resection can be safely achieved in the vast majority of IMSCTs when an intraoperatively identified tumor plane is identified, independent of pathological type.
Journal ArticleDOI
Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part I: Treatment modalities of radiation therapy.
Rolf-Dieter Kortmann,Beate Timmermann,Roger E. Taylor,Giovanni Scarzello,Ludwig Plasswilm,Frank Paulsen,Branislav Jeremic,Astrid Gnekow,Karin Dieckmann,Sylvia Kay,Michael Bamberg +10 more
TL;DR: Radiation therapy is an effective treatment modality in children with low-grade glioma regarding tumor control and improvement and/or preservation of neurologic function or vision, respectively.
Journal ArticleDOI
Results of positron emission tomography guidance and reassessment of the utility of and indications for stereotactic biopsy in children with infiltrative brainstem tumors
TL;DR: The suggestion that PET guidance improves the diagnostic yield of stereotactic biopsy sampling, allows the practitioner to reduce the number of sampling procedures, and might lead to a reassessment of the utility of and indications for stereotactically guided biopsy in children with intrinsic infiltrative brainstem lesions is supported.
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TL;DR: This work suggests "new" response criteria for phase II studies of supratentorial malignant glioma and favor rigorous criteria similar to those in medical oncology, with important modifications, to minimize misinterpretations of response.
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Postoperative irradiation for subtotally resected meningiomas: A retrospective analysis of 140 patients treated from 1967 to 1990
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Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood
Roger J. Packer,Beverly J. Lange,Joann L. Ater,H S Nicholson,Jeffrey C. Allen,R Walker,Michael D. Prados,Regina I. Jakacki,Gregory H. Reaman,M N Needles +9 more
TL;DR: Carboplatin and vincristine have activity in children with recurrent and newly diagnosed progressive LGGs and Objective responses to treatment after chemotherapy can be seen.