Journal ArticleDOI
Low Level Radiation and Genetic Risk Estimation in Man
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TLDR
A large-scale study of Mendelian Mutants, radiation and Down's Syndrome, and the human spontaneous genetic burden found that the former is more common than the latter.Abstract:
INTRODUCTION 329 KINDS OF MUTATIONAL DAMAGE .. . ...... ....... 330 Mendelian Mutants 330 Chromosome Aberrations 330 Irregularly Inherited Disorders 331 THE RISK ESTIMATES 331 METHODS OF CALCULATION 332 The Doubling Dose Method 332 Mutation Component 335 The Direct Methods 336 First generation dominants 336 The problem of stating uncertainty 337 Translocations 338 Gene Number Methods 339 DATA 341 The Human Data 341 The human spontaneous genetic burden 341 The Japanese cohort 342 Radiation and Down's Syndrome 344 The Mouse Data 346 Opposing Viewpoints 347 CONCLUSION 352read more
Citations
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Every pediatrician a geneticist (1983): (with an evolutionary view of disease)
Journal ArticleDOI
Induction of congenital malformations in the offspring of male mice treated with X-rays at pre-meiotic and post-meiotic stages.
TL;DR: The relative sensitivities of male stem cells, post-neiotic stages and mature oocytes to the induction of congenital malformations were reasonably similar to their sensitivities for specific-locus mutations, except that the expected enhancing effect of the fractionation regime used was not seen.
Journal ArticleDOI
The effect of Mendelian disease on human health: a measurement.
TL;DR: An attempt to measure effects of Mendelian phenotypes on human health (homeostasis) in man found most phenotypes compatible with life beyond infancy caused psychosocial handicap and limited the access to schooling and work.
Journal ArticleDOI
Ionizing radiation and genetic risks. XIII. Summary and synthesis of papers VI to XII and estimates of genetic risks in the year 2000.
TL;DR: In this article, the authors presented revised estimates of genetic risks of exposure to radiation, including Mendelian and chronic multifactorial diseases, based on mouse data on developmental abnormalities.
References
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Journal ArticleDOI
The inheritance of liability to certain diseases, estimated from the incidence among relatives
TL;DR: The purpose of this paper is to suggest that the method developed in quantitative genetics for dealing with ‘threshold characters ’ is applicable to data on the incidence of diseases, and that by its use the authors can get further towards an answer to the question of the relative importance of heredity and environment.
Book ChapterDOI
Mutation Induction in Mice
TL;DR: This chapter reviews gene or point mutations and discusses the fine structure of mutation-induced point mutations in mice and finds that with postnatal irradiation at any age, the progeny will be derived from irradiated dictyate oocytes, unless fertilization of the eggs takes place within 12 hours of the irradiation.
Journal ArticleDOI
Uniformity of radiation-induced mutation rates among different species.
TL;DR: One of the major difficulties in estimating the genetic hazards of ionising radiation to human populations has been the inability to extrapolate with confidence from mutation rate data in lower organisms to man1,2.
Journal ArticleDOI
Analysis of x-ray-induced chromosomal translocations in human and marmoset spermatogonial stem cells
TL;DR: The mouse is the mammal currently used as the model for estimating man's genetic risk from mutagenic exposure, and Brewen and Preston's earlier observations on germ cells should be extended to include a primate and man if possible.
Journal ArticleDOI
Gamma-Ray-Induced Dominant Murtation That Cause Skeletal Abnormalities In Mice
Paul B. Selby,Patricia R. Selby +1 more
TL;DR: The data suggest that the present presumed-mutation criteria can identify about one-half of all dominant skeletal mutations on the basis of the skeletal examination alone, which should give very few, if any, false positives.