Seymour Abrahamson

TL;DR: The test for sex-linked recessive lethals in Drosophila melanogaster has been used to detect induced mutations since 1927 and there were sufficient data available in the literature for analysis; 198 compounds were found to be positive and 46 negative at the highest concentration tested.

TL;DR: One of the major difficulties in estimating the genetic hazards of ionising radiation to human populations has been the inability to extrapolate with confidence from mutation rate data in lower organisms to man1,2.

TL;DR: A re-analysis of published data on mouse mutation rates suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve, based on the assumption that the shape of the dose curve reflects the manner in which the mutations are induced rather than representing a one-track (linear) curve whose shape has been modified by differential repair.

TL;DR: The term "chromosome mutations" refers to alterations of chromosome structure (reciprocal, heritable translocations), of chromosome number (loss or gain of a whole chromosome), or of chromosome content (loss of a part of a chromosome) Chromosome mutation may result from chromosome breakage (clastogenesis) and its consequences or from disruption of chromosome behavior during cell division (nondisjunction) as mentioned in this paper.

TL;DR: In this, his first paper on the subject, H. J. MULLER reported the first experimental production of mutations and opened a new era in genetics, and suggested mutation as a cause of cancer.