Low-renin hypertension
TLDR
Critical issues will be addressed are whether this represents a volume expansion type of hypertension; whether an unidentified mineralocorticoid accounts for this syndrome; what, if any, its prognostic implications are; and how it should be treated.About:
This article is published in Kidney International.The article was published on 1974-05-01 and is currently open access. It has received 164 citations till now. The article focuses on the topics: Essential hypertension & Primary aldosteronism.read more
Citations
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Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension
TL;DR: Dahl's original hypothesis, that the kidney's control of sodium excretion is paramount in the control of blood pressure, is used to form a possible explanation for the origins of essential hypertension.
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Antihypertensive beta blocking action as related to renin and age: a pharmacologic tool to identify pathogenetic mechanisms in essential hypertension.
TL;DR: Three hundred fifteen patients with essential hypertension were classified according to low (18 percent), normal (59 percent) or high (23 percent) renin-sodium index, and two high renin groups emerged: a younger group with early moderate hypertension, and an older group with severe hypertension consequent to possibly ischemic renal disease.
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Effects of volume expansion and contraction in normotensive whites, blacks, and subjects of different ages.
TL;DR: The greater prevalence of hypertension in both blacks and older subjects may be related to relatively blunted natriuretic responses when these groups engage in the high sodium-low potassium intake characteristic of the authors' society.
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Detection of renovascular hypertension. State of the art: 1992.
TL;DR: These tests differentiate renovascular hypertension from essential hypertension more reliably than from asymmetric renal parenchymal disease; however, they do not reliably distinguish unilateral from bilateral stenosis and are not recommended for use in patients with a low likelihood of disease.
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Animal models of hypertension: an overview.
TL;DR: The phenotype-driven approach is taking advantage of selective breeding of animals (primarily rats) that exhibit a desired phenotype, like the useful SHR as mentioned in this paper, which allows dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits, and cellular responses to injury.
References
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Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129mmHg
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Essential hypertension: renin and aldosterone, heart attack and stroke
Hans R. Brunner,John H. Laragh,Leslie Baer,Michael A. Newton,Frank T. Goodwin,Lawrence R. Krakoff,Richard H. Bard,Fritz R. Bühler +7 more
TL;DR: Plasma renin activity emerges as a potential risk factor for patients with essential hypertension — useful for identifying etiologies, determining prognosis and applying therapy.
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Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases.
TL;DR: The drug was uniformly effective in 13 patients with high renin activity and malignant, renovascular, or essential hypertension, producing a mean fall in diastolic pressure of 30 mm of mercury, but individual responses were less consistent.
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Control of renin release.
TL;DR: Theories Proposed for Control of Renin Release and the role of angiotensin are proposed.
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Vasoconstriction-Volume Analysis for Understanding and Treating Hypertension: The Use of Renin and Aldosterone Profiles
TL;DR: This bipolar analysis assumes that chronic hypertension is maintained by (1) arterial overfilling (volume hypertension), (2) arteriolar constriction without increased volume (vasoconstrictor hypertension) or (3) an inappropriate interaction of the two.