Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension
TLDR
Dahl's original hypothesis, that the kidney's control of sodium excretion is paramount in the control of blood pressure, is used to form a possible explanation for the origins of essential hypertension.About:
This article is published in Kidney International.The article was published on 1980-07-01 and is currently open access. It has received 393 citations till now. The article focuses on the topics: Blood pressure & Essential hypertension.read more
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Sodium/Calcium Exchange: Its Physiological Implications
TL;DR: In cardiac myocytes, and probably other cell types, the exchanger serves a housekeeping role by maintaining a low intracellular Ca2+ concentration; its possible role in cardiac excitation-contraction coupling is controversial.
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A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension
John M. Hamlyn,Richard Ringel,Juergen Schaeffer,Paul Levinson,Bruce P. Hamilton,A. Avinoam Kowarski,Mordecai P. Blaustein +6 more
TL;DR: A highly significant correlation is demonstrated between levels of a plasma inhibitor of (Na+ + K+)ATPase activity and mean arterial blood pressure in normotensive and hypertensive individuals, providing evidence for the involvement of a circulating Na+ pump inhibitor in the genesis of essential hypertension.
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Atrial natriuretic hormone, the renin-aldosterone axis, and blood pressure-electrolyte homeostasis.
TL;DR: The renin-angiotensin-aldosterone axis exerts major control over sodium and potassium balance and arterial blood pressure as discussed by the authors, and this has led investigators to search for other natriuretic hormonal mechanisms.
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Salt sensitivity in hypertension. Renal and cardiovascular implications.
TL;DR: In conclusion, salt sensitivity in hypertension is associated with substantial renal, hemodynamic, and metabolic abnormalities that may enhance the risk of cardiovascular and renal morbidity.
Dietary Reference Intakes
TL;DR: The development of DRIs replaces the periodic revisions of Recommended Dietary Allowances (RDAs), which have been published since 1941 by the National Academy of Sciences.
References
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Journal Article
Development of a Strain of Spontaneously Hypertensive Rats
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: The incidence of the spontaneous occurrence of hypertension increased, the development of hypertension occurred at younger ages from generation to generation, and all of the F3 to F6, rats developed spontaneous hypertension within 15 weeks of age.
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Development of a strain of spontaneously hypertensive rats.
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: Okamoto-Aoki et al. as discussed by the authors found that the spontaneous occurrence of hypertension increased with age and the development of hypertension occurred at younger ages from generation to generation, increasing significantly above those of normotensive controls of the same age.
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Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis
TL;DR: The cellular mechanisms which may account for the well-documented correlation between sodium metabolism and peripheral vascular resistance are elucidated and the evidence that the Na electrochemical gradient across the sarcolemma plays an important role in cell calcium regulation is reviewed.
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Effects of chronic excess salt ingestion evidence that genetic factors play an important role in susceptibility to experimental hypertension
TL;DR: Using the genetic technique of selective inbreeding, it has been possible to quickly develop two statistically separable populations from one unselected strain of Sprague-Dawley rats, one of these very sensitive, the other very resistant, to the development of experimental hypertension from a high salt diet.
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Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture.
TL;DR: The Yanomamo Indians are an unacculturated tribe inhabiting the tropical equatorial rain forest of northern Brazil and southern Venezuela who do not use salt in their diet, which presented an unusual opportunity to study the hormonal regulation of sodium metabolism in a culture with life-long extreme restriction of dietary sodium.