Journal ArticleDOI
Lymphocyte function of Michigan dairy farmers exposed to polybrominated biphenyls
J. George Bekesi,James F. Holland,Henry A. Anderson,Alf Fischbein,William N. Rom,Mary S. Wolff,Irving J. Selikoff +6 more
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Michigan dairy farm residents ate farm products containing polybrominated biphenyls after the accidential contamination of animal feed with the chemical in that state in 1973 show significant changes in circulating blood lymphocytes, but there appears to be no consistent correlation between the concentration of PBB's in the plasma and the altered lymphocytes.Abstract:
Michigan dairy farm residents ate farm products containing polybrominated biphenyls (PBB's) after the accidential contamination of animal feed with the chemical in that state in 1973. The circulating blood lymphocytes of these residents show significant changes. Abnormalities include decreases in the numbers and percentages of peripheral blood lymphocytes that form rosettes with either sheep erythrocytes alone or with sheep erythrocytes sensitized with antibody and complement, increases in lymphocytes with no detectable surface markers ("null" cells), and altered responses to tests designed to evaluate functional integrity of the cells. There appears to be no consistent correlation between the concentration of PBB's in the plasma and the altered lymphocytes. Studies showed that in Wisconsin dairy farm residents and healthy individuals in the New York area who were not exposed to PBB's there were no such abnormalities.read more
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References
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Journal ArticleDOI
Thymus-Derived Rosette-Forming Cells in Various Human Disease States: Cancer, Lymphoma, Bacterial and Viral Infections, and Other Diseases
Joseph Wybran,H. Hugh Fudenberg +1 more
TL;DR: It appears that the percentage of RFC may be valuable in evaluating not only immunological defenses but also the status of patients with solid tumors, lymphomas, viral diseases and, perhaps, bacterial infections.
Book ChapterDOI
Receptors for Immune Complexes on Lymphocytes
TL;DR: The study of the mechanism of interaction of immune complexes with lymphocytes may be of relevance to several important areas of immunological research as well as to the understanding of mechanisms of disease.
Journal Article
A toxic syndrome associated with the feeding of polybrominated biphenyl-contaminated protein concentrate to dairy cattle.
Jackson Tf,Halbert Fl +1 more
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Identification by peroxidase staining of monocytes in surface immunofluorescence tests.
TL;DR: Two approaches may be used in order to avoid erroneous interpretation due to monocytes, either the use of cell suspensions free of monocytes or the identification of monocytic cells.
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