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Showing papers in "Environmental Research in 1977"


Journal ArticleDOI
TL;DR: A working hypothesis on the pathogenetic mechanism of mercury on the nervous system is proposed and it was found that the sensory neurons in the spinal ganglia and granule cells in the cerebellum were most vulnerable to mercury poisoning.

271 citations


Journal ArticleDOI
TL;DR: Claims of continuing ill effects to animals and man from PBB contamination over the past 3 years in Michigan have engendered intense activity at government level to establish the role of PBB and bring the problem to an effective solution.

149 citations


Journal ArticleDOI
TL;DR: In the group of 185 persons continuously exposed to cadmium dust in the work environment, the prevalence of increased urinary ..beta../sub 2/-microglobulin excretion increased with employment time, and Smokers had about three times higher prevalence than nonsmokers.

109 citations


Journal ArticleDOI
TL;DR: Increased excretion was strongly related to residence time in the exposed area as well as to the use of contaminated river water in the household, and there was a correlation between cadmium levels in the blood and β 2 -microglobulin excretion.

109 citations


Journal ArticleDOI
TL;DR: The assessment of medical and biochemical effects of chronic lead exposure and comparing the usefulness of various biological screening parameters and the effects of chelation therapy to control blood lead levels in lead workers are concerned with.

108 citations


Journal ArticleDOI
TL;DR: Both chrysotile fibers from human lungs and from in vitro incubation with AM have shown an increase of the Si:Mg ratio in respect to standard fibers, and the results have shown that the magnesium leakage was not constant along the fiber axis and was different from one fiber to another.

100 citations


Journal ArticleDOI
TL;DR: A significant correlation was found between zeta potential and hemolytic activity for all five UICC samples, which suggests that surface charge is the principal factor in hemolysis by asbestos.

99 citations


Journal ArticleDOI
TL;DR: Chlorella pyrenoidosa is capable of concentrating cadmium, and the amount accumulated is directly proportional to the concentration of metal present initially and is dependent upon the pH of the medium.

91 citations


Journal ArticleDOI
TL;DR: There is benefit to studying those in the general population who have such occupational exposure beyond that achieved by studying a working occupational group in a plant setting.

84 citations


Journal ArticleDOI
TL;DR: The results corresponded to the theoretical ideas on spreading of emissions from elevated sources in the open air and tend to establish the applicability of arsenic determination in the hair as a direct exposure test of contamination of the environment by arsenic.

82 citations


Journal ArticleDOI
TL;DR: Hearing changes were analyzed after audiometric and clinical otorhinolaryngological examination of a group of 56 10-year-old children residing near a power plant burning local coal of high arsenic content and found significant degrees of hearing loss were found in bone conduction as well as in the corresponding ranges of frequencies.

Journal ArticleDOI
TL;DR: Current standards on permissive daily exposure to toxic heavy metals should be carefully reconsidered, taking into account the specificities of behavior of heavy metals in growing organism.

Journal ArticleDOI
TL;DR: Excess mortalities observed after 20 daily 3-hour exposures suggested that a synergistic effect might be present upon repeated inhalation of pollutant mixtures, that made them more effective in reducing resistance to respiratory infection.

Journal ArticleDOI
TL;DR: The data suggest quantitative differences in the ability of these tissues to metabolize and/or store organochlorine compounds and emphasize the importance of the maternal organism in protection of the fetus against environmental hazards.

Journal ArticleDOI
TL;DR: Radioimmunoassay of β2-microglobulin in urine is a sensitive indicator of cadmium-induced proteinuria in people with Itai-itai disease and glomerular kidney disease, as well as on samples from a reference group.

Journal ArticleDOI
Robert N. Sawyer1
TL;DR: This report presents data obtained from 200 samples examined to date and outlines procedures used in the operation to eliminate potentially carcinogenic asbestos exposures in the Yale University Art and Architecture building.

Journal ArticleDOI
TL;DR: Tissue samples from the cerebellum were obtained for electron microscopy from mice which were prenatally exposed to methyl mercury and Lysosomal accumulation was observed in both the Purkinje neurons and granule cells.

Journal ArticleDOI
TL;DR: Mirex readily crosses the rat placental barrier; while no teratogenic effects are apparent, reduced litter size and a high incidence of cataracts in the offspring have been reported.

Journal ArticleDOI
TL;DR: Zinc was shown to accumulate with age in the kidney cortex in a way similar to cadmium, and had a log-normal distribution in the liver and pancreas.

Journal ArticleDOI
TL;DR: It is concluded that a single high dose of PBB can be embryolethal and teratogenic to the rat embryo.

Journal ArticleDOI
TL;DR: These two treatments are synergistic in that combinations of minimal teratogenic levels of each cause a marked increase in fetal resorptions and the frequency and severity of developmental malformations as compared to separate treatments.

Journal ArticleDOI
TL;DR: Evidence is provided that minute amounts of methylmercury, which by itself may produce no significant injury to the maternal tissues nor any observable gross teratology of the neonate, may still be hazardous to the developing nervous system.

Journal ArticleDOI
TL;DR: It is concluded that age bears a significant influence on cadmium metabolism and might be important for estimating cad mium body burden and critical organ exposure in the youngest age group.

Journal ArticleDOI
TL;DR: Although the mechanism of production of membranous nephropathy in these cases is not known, an indirect immunological process mediated by endogenous tubular antigen is suggested and Examination for proteinuria is a simple method of screening in cases.

Journal ArticleDOI
TL;DR: Tubular proteinuria increased with age and with exposure duration and increased total proteinuria was also more common in the exposed group but the prevalence rate ratio was 2.4 as compared to 4.4 for tubularproteinuria.

Journal ArticleDOI
TL;DR: It follows from the data presented that inhalation of this metal can inhibit the normal mucociliary function vital for clearance of agents from the respiratory tract.

Journal ArticleDOI
TL;DR: Tin-113-labeled bis-tributyltin oxide, TBTO, has been prepared from metallic 113 Sn and the turnover rate of TBTO in the mice appeared to become asymptotic to that of inorganic tin.

Journal ArticleDOI
TL;DR: By comparing the concentration of elements in lichens belonging to the genus Parmelia to that of atmospheric particulates in the city of Sendai, Japan, it is suggested that these lichens may be useful as sensors of air pollution, but the different accumulation of elements should be taken into consideration.

Journal ArticleDOI
TL;DR: Pathological, histochemical, and analytical studies have confirmed the presence of Minamata Disease in at least one of two cats that lived on or near Indian Reserves in Northwestern Ontario, Canada, and symptoms parallel the Japanese experience in the 1950s.

Journal ArticleDOI
TL;DR: A dose-response relationship was found between the amount of smoking and the PbB concentrations of men occupationally exposed to lead, and smokers had statistically significantly higher Pb-B levels than nonsmokers.