Journal ArticleDOI
Lymphocytes binding human thyroglobulin in healthy people and its relevance to tolerance for autoantigens
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Lymphocytes of eleven normal subjects were studied with autoradiographic techniques for the presence of cells which bind human 125 I-thyroglobulin (Tg) and identified primarily as B lymphocytes in four patients by their marked or complete depletion after passage through this column.About:
This article is published in The Lancet.The article was published on 1973-02-03. It has received 139 citations till now. The article focuses on the topics: Antigen & Lymphocyte.read more
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Journal ArticleDOI
Role of aberrant hla-dr expression and antigen presentation in induction of endocrine autoimmunity
TL;DR: This mechanism of autoimmune disease induction explains vague associations with viral infections and long latency periods before disease becomes manifest and gives a simple explanation for the well-documented association between HLA-DR and autoimmune diseases in man.
Journal ArticleDOI
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
TL;DR: The autoimmune disease induced in nude mice was quite similar to human organ-specific autoimmune disease in terms of the spectrum of organs involved, histopathological features, and the development of autoantibodies to corresponding organ components.
Journal ArticleDOI
Etiopathogenesis of Murine SLE1
TL;DR: The prevailing current concept is that self-recognition processes, essential to immune and possibly other physiologic systems, are normally controlled or suppressed by one or more mechanisms that counteract deleterious autoreactive consequences.
Book ChapterDOI
Ionizing radiation and the immune response.
TL;DR: This chapter considers the interrelationships between radiation and the various components of the immune response from three perspectives: the effect of irradiation on normal lymphoid tissues and on isolated lymphocytes, the effect on antibody production, transplantation immunity, and other forms of cellular immunity.
Book ChapterDOI
Membrane immunoglobulins and antigen receptors on B and T lymphocytes.
TL;DR: There are several qualitative and quantitative distinctions between T-cell and B-cell M-Ig that may explain many of the apparent differences in reactivity of these cells without requiring the existence of a different set of V genes or non-IG receptors in T cells.
References
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Book
The clonal selection theory of acquired immunity
TL;DR: The clonal selection theory of acquired immunity is studied as a theory of selection for immunity in the context of infectious disease.
Journal ArticleDOI
Immunoglobulins on the surface of lymphocytes : i. distribution and quantitation
TL;DR: A variety of observations make it likely that this lymphocyte-associated immunoglobulin.
Journal ArticleDOI
A receptor for antibody on b lymphocytes : i. method of detection and functional significance
TL;DR: It was proposed that the existence of a receptor of this kind may provide a rational explanation for antibody-dependent killing of target cells and may prove of importance in antigen concentration particularly during the secondary response.
Journal ArticleDOI
Infection by penicillin-resistant staphylococci
Journal Article
Infection with penicillin resistant staphylococci
Rozwadowska-Dowzenko M,Lamers H +1 more