Journal ArticleDOI
Lymphocytic hypophysitis: modern day management with limited role for surgery
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TLDR
There remains a significant time lag between the onset of symptoms and the eventual diagnosis of LH, and despite the considerable morbidity attached to LH, overall prognosis is good.Abstract:
We set out to describe the modern day management of Lymphocytic hypophysitis (LH) with respect to its diagnosis, treatment and long-term endocrine and visual outcomes. We deliberately included patients with a clinical diagnosis of LH and compared them with those with a histological diagnosis following surgery. A multi-centre observational study was performed. Twenty-two patients were included and studied over a mean follow-up period of 8.6 years (range 4–26 years). Patients presented with headache (N = 15; 68 %), visual field disturbances (N = 7; 32 %) or a combination of these symptoms (N = 5; 23 %). The time lag between onset of symptoms and diagnosis was 6 months in approximately a third of the patients each, respectively. In two-thirds of the patients (N = 14) LH was diagnosed based on their clinical, biochemical and radiological findings. The surgical cohort (N = 8) was statistically more likely to have presented with larger lesions, with suprasellar extension and greater visual field defects. During follow-up there was improvement in headaches and visual symptoms, but the rate of hypopituitarism as reflected by the need for on-going pituitary hormone replacement persisted. At the 1, 5 and 10 year follow-up there was no significant difference between the medically and surgically managed cohorts in terms of ongoing symptomatology or need for pituitary hormone replacement. In the modern era, most patients with LH are diagnosed by non-surgical means and managed medically. There remains a significant time lag between the onset of symptoms and the eventual diagnosis of LH. Despite the considerable morbidity attached to LH, overall prognosis is good.read more
Citations
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Journal ArticleDOI
Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years.
Shuchang Wang,Linjie Wang,Yong Yao,Feng Feng,Hongbo Yang,Zhiyong Liang,Kan Deng,Hui You,Jian Sun,Bing Xing,Zimeng Jin,Renzhi Wang,Hui Pan,Huijuan Zhu +13 more
TL;DR: This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort of patients with a history of lymphocytic hypophysitis.
Journal ArticleDOI
Hypophysitis Outcome and Factors Predicting Responsiveness to Glucocorticoid Therapy: A Prospective and Double-Arm Study.
Sabrina Chiloiro,Tommaso Tartaglione,Ettore Capoluongo,Flavia Angelini,Vincenzo Arena,Antonella Giampietro,Antonio Bianchi,Angelo Zoli,Alfredo Pontecorvi,Cesare Colosimo,Laura De Marinis +10 more
TL;DR: Glucocorticoid treatment of hypophysitis improves pituitary secretion and should be encouraged in accordance with the evaluation of endocrine-, immunological-, and morphological-predictive markers.
Journal ArticleDOI
The Changing Clinical Spectrum of Hypophysitis.
Sabrina Chiloiro,Ettore Capoluongo,Tommaso Tartaglione,Antonella Giampietro,Antonio Bianchi,Andrea Giustina,Alfredo Pontecorvi,Laura De Marinis +7 more
TL;DR: A diagnostic and therapeutic protocol that should be focused on a multidisciplinary approach, for reaching a prompt diagnosis and an appropriate and safe treatment of hypophysitis is suggested.
Journal ArticleDOI
Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.
TL;DR: In this paper, the authors defined hypophysitis as inflammation of the pituitary gland that is primary or secondary to a local or systemic process, such as primary tumors, metastases, and lympho-proliferative diseases.
References
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Journal ArticleDOI
Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma.
Alexander T. Faje,Ryan J. Sullivan,Donald P. Lawrence,Nicholas A. Tritos,Riley Fadden,Anne Klibanski,Lisa B. Nachtigall +6 more
TL;DR: Diffuse pituitary enlargement was observed exclusively in all cases of IH and, upon retrospective review of magnetic resonance imaging scans, this finding preceded the clinical diagnosis of hypophysitis in eight patients.
Journal ArticleDOI
Lymphocytic hypophysitis: a rare or underestimated disease?
Antonio Bellastella,Antonio Bizzarro,Concetta Coronella,Giuseppe Bellastella,Antonio Agostino Sinisi,Annamaria De Bellis +5 more
TL;DR: Among the 'isolated' pituitary hormone deficiencies, ACTH deficit is usually the earliest and most frequent hormonal impairment and in rare cases can induce an acute secondary hyposurrenalism as the first sign of the disease, with high mortality in affected patients.
Journal ArticleDOI
Lymphocytic and Granulomatous Hypophysitis: Experience with Nine Cases
Jürgen Honegger,Rudolf Fahlbusch,Antje Bornemann,Johannes Hensen,Michael Buchfelder,Marion Müller,P. Nomikos +6 more
TL;DR: Lymphocytic Hypophysitis and granulomatous hypophysitis represent related inflammatory disorders and their conspicuous clinical features frequently allow preoperative diagnosis ofHypophysitis.
Journal ArticleDOI
The Spectrum and Significance of Primary Hypophysitis
TL;DR: It is concluded that the optimal management of patients with hyophysitis requires a high index of suspicion before extensive surgical resection, and conservative, supportive treatment with or without surgical decompression is generally favored over aggressive and extensive surgery resection that results in hypopituitarism.