Journal ArticleDOI
Lysine control of penicillin biosynthesis
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The known diminution in penicillin formation by added lysine is thought to occur via feedback regulation of the lysin biosynthetic pathway, thus depleting the cells of α-aminoadipic acid, a precur...Abstract:
The known diminution in penicillin formation by added lysine is thought to occur via feedback regulation of the lysine biosynthetic pathway, thus depleting the cells of α-aminoadipic acid, a precur...read more
Citations
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Journal ArticleDOI
Evaluation of feeding strategies in carbon‐regulated secondary metabolite production through mathematical modeling
R. K. Bajpai,M. Reuß +1 more
TL;DR: In this article, a mechanistic model involving a substrate inhibition kinetics of product formation has been verified in simulation of penicillin fermentation data obtained from the literature, and a complicated computer guided strategy based upon controlling biomass growth rates in the tropo and idiophases has been investigated.
Journal ArticleDOI
Lysine inhibition of in vivo homocitrate synthesis in Penicillium chrysogenum.
A. L. Demain,P. S. Masurekar +1 more
TL;DR: Results indicate that lysine diminution of penicillin production is caused by feedback inhibition of homocitrate synthase, thus limiting the supply of α-aminoadipic acid available forPenicillin biosynthesis.
Journal ArticleDOI
Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum.
TL;DR: In vitro studies indicated that L-lysine feedback inhibits and represses homocitrate synthase both in low- and high-penicillin-producing strains, including Penicillium chrysogenum.
Journal ArticleDOI
Isolation and characterization of the acetyl-CoA synthetase from Penicillium chrysogenum. Involvement of this enzyme in the biosynthesis of penicillins.
Honorina Martínez-Blanco,Angel Reglero,Martiniano Fernández-Valverde,Miguel A. Ferrero,Miguel A. Moreno,M A Peñalva,José M. Luengo +6 more
TL;DR: Results strongly indicate that this enzyme can catalyze the activation (to their CoA thioesters) of some of the side-chain precursors required in these two fungi for the production of several penicillins.
References
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Journal ArticleDOI
A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
TL;DR: A modification of the naphthalene-dioxane-PPO liquid scintillator has been described which will allow up to 3.0 ml of an aqueous solution to be counted as mentioned in this paper.
Journal ArticleDOI
Reversal of lysine inhibition of penicillin production by α-aminoadipic or adipic acid
TL;DR: The data suggest, that α-aminoadipic acid has a role in penicillin biosynthesis; lysine apparently interferes with this role.
Journal ArticleDOI
Inhibition of penicillin formation by amino acid analogs.
TL;DR: Using resting mycelial suspensions, it was found that S -ethyl- dl -cysteine and α-methyl- d l -valine inhibit penicillin synthesis from lactose.
Related Papers (5)
Lysine inhibition of in vivo homocitrate synthesis in Penicillium chrysogenum.
A. L. Demain,P. S. Masurekar +1 more