Journal ArticleDOI
Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma
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TLDR
It is suggested that MTL and Western cases of primary FCC gastrointestinal lymphoma share a common histogenesis from mucosa associated lymphoid tissue.Abstract:
As illustrated in the two cases described in this paper close morphologic and immunohistochemical similarities exist between Mediterranean lymphoma (MTL) and primary gastrointestinal lymphoma of follicle center cell (FCC) origin as it occurs in Western countries. Similarities between the two conditions include a dense noninvasive monotypic lamina propria plasma cell infiltrate, present in all cases of MTL and in some cases of Western gastrointestinal FCC lymphoma, and an invasive infiltrate of FCCs morphologically distinct from the plasma cells. A distinctive lesion produced by individual gland invasion characterizes both types of lymphoma. A clonal relationship between the lamina propria plasma cells and the invasive FCCs, long suspected but never proved in MTL, can be demonstrated in Western cases. Many of the histologic and clinical features common to these lymphomas can be explained in the context of the normal maturation sequences of gut associated lymphoid tissue. It is suggested that MTL and Western cases of primary FCC gastrointestinal lymphoma share a common histogenesis from mucosa associated lymphoid tissue.read more
Citations
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Journal ArticleDOI
A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma
A clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin's lymphoma: a report of the Non-Hodgkin's Lymphoma Classification Project
James R. Anderson,James O. Armitage,Françoise Berger,F Cavalli,WC Chan,J Close,B Coiffier,J Connors,J Diebold,Randy D. Gascoyne,N Harris,W Hiddemann,Fcs Ho,P Jacobs,Rhs Liang,TA Lister,Kenneth A. MacLennan,HK Muller-Hermelink,Bharat N. Nathwani,A Norton,G Ott,E Pedrinis,Pooja Roy,A Schauer,D. D. Weisenburger +24 more
Journal ArticleDOI
Malignant lymphoma of mucosa‐associated lymphoid tissue
Peter G. Isaacson,Jo Spencer +1 more
TL;DR: In this paper their morphological features are reviewed; recent findings based on immunohistochemistry and DNA analysis are presented; and the biological behaviour of these tumours is discussed insofar as they offer insight into mucosal immunological mechanisms.
Journal ArticleDOI
Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue.
TL;DR: Four cases of extranodal malignant lymphoma, one each arising in the stomach, salivary gland, lung, and thyroid, are described and it is proposed that this is because they share a common pattern of histogenesis from mucosa‐associated lymphoid tissue (MALT).
Journal ArticleDOI
Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed
Catherine Thieblemont,Françoise Berger,Charles Dumontet,Isabelle Moullet,Fadhela Bouafia,Pascale Felman,Gilles Salles,Bertrand Coiffier +7 more
TL;DR: MALT lymphoma is an indolent disease but presents as a disseminated disease in one-third of the cases at diagnosis, and the dissemination does not change the outcome of the patients.
References
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Journal Article
Evidence for a Common Mucosal Immunologic System I. Migration of B Immunoblasts Into Intestinal, Respiratory, and Genital Tissues
TL;DR: The origins of immunoglobulin-containing cells in intestinal, respiratory, mammary, and genital tissues were studied in CBA/J female mice by using an adoptive lymphocyte transfer method and data support the concept of a common mucosal immunologic system.
Journal ArticleDOI
The origin and antigen-dependent distribution of IgA-containing cells in the intestine.
A J Husband,J L Gowans +1 more
TL;DR: The aims of this paper were to establish the origin of cells producing IgA antibody to cholera toxoid in the lamina propria of the small intestine and to define the role of antigen in their distribution.
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Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas.
TL;DR: Investigating the immunohistologic architecture of follicular centroblastic/centrocytic lymphoma showed a more or less close similarity to the organization of secondary follicles, which confirmed that this lymphoma was composed of a neoplastic T zone and a non-malignant B zone.
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The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique.
TL;DR: Treatment of sections with trypsin prior to the use of the unlabelled antibody-enzyme method using PAP renders the technique reliable, provided the enzyme is used in a carefully controlled manner.
Journal ArticleDOI
Alpha-chain disease: a new immunoglobulin abnormality.
TL;DR: A new type of pathological immunoglobulin was found in the serum, urine, and saliva of a young Arab patient with abdominal lymphoma and diffuse lymphoplasmacytic infiltration of the small intestine.