Massive Brain Hemorrhage: A Review of 144 Cases and an Examination of Their Causes
TLDR
The data would indicate the need for a critical study of the causes of intracranial hemorrhages, and re-evaluation of the true relationship of systemic hypertension to such strokes, and the widespread dogma that hypertension is the outstanding cause of nontraumatic brain hemorrhage no longer seems warranted.Abstract:
A detailed clinicopathological study of the causes and locations of massive nontraumatic brain hemorrhage in 144 patients is reported. A cause of the hemorrhage, such as an aneurysm, angioma, arteritis, neoplasm or a blood dyscrasia (leukemia, hemophilia), was proved in two-thirds (95) of these patients. Twelve normotensive patients had no cause found to explain their hemorrhage. Systemic hypertension, generally mild, defined as a pre-ictal pressure of > 140/90 or by excessive heart weight, was present in 58 of the 144 patients. Twenty-one of these 58 hypertensive patients had a clear discernible cause for their brain hemorrhage (i.e., leukemia, metastatic carcinoma, angioma, aneurysm), whereas no satisfactory morphological cause could be found in only 37. Thus, in only about one-fourth of our patients could any serious claim be made that hypertension was the cause of the hemorrhage. Our data would indicate the need for a critical study of the causes of intracranial hemorrhages, and re-evaluation of the t...read more
Citations
More filters
Journal ArticleDOI
Cerebral amyloid angiopathy. A critical review.
TL;DR: The purpose of which is to review the clinicopathologic features of CAA, emphasizing theories of pathogenesis and its importance as a cause of brain hemorrhage.
Journal ArticleDOI
Management of Stroke in Infants and Children A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young
E. Steve Roach,Meredith R. Golomb,Robert J. Adams,José Biller,Stephen R. Daniels,Gabrielle deVeber,Donna M. Ferriero,Blaise V. Jones,Fenella J. Kirkham,R. Michael Scott,Edward R. Smith +10 more
TL;DR: Evidence-based recommendations are provided for the prevention of ischemic stroke caused by sickle cell disease, moyamoya disease, cervicocephalic arterial dissection, and cardiogenic embolism.
Journal ArticleDOI
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.
J. P. Vonsattel,Richard H. Myers,E. T. Hedley-Whyte,Allan H. Ropper,Edward D. Bird,Edward P. Richardson +5 more
TL;DR: The features of brains from patients with CAA that are most consistently related to cerebral hemorrhage are a severe degree of CAA and the presence of fibrinoid necrosis, with or without microaneurysms.
Journal ArticleDOI
Risk of spontaneous haemorrhage after diagnosis of cerebral arteriovenous malformation
Henning Mast,William L. Young,Hans-Christian Koennecke,Robert R. Sciacca,Andrei Osipov,John Pile-Spellman,Lotfi Hacein-Bey,Hoang Duong,Bennett M. Stein,J. P. Mohr +9 more
TL;DR: In AVM, patients initially presenting with haemorrhage have a higher risk of subsequent bleeding than those presenting with other symptoms, and the risk is higher in men than in women.
Journal ArticleDOI
A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults
Rustam Al-Shahi,Charles P Warlow +1 more
TL;DR: There is a pressing need for large, prospective studies of the frequency and clinical course of AVMs in well-defined, stable populations, taking account of their prognostic heterogeneity.
References
More filters
Journal ArticleDOI
Hypertension: Deficient Care of the Medically Served
TL;DR: Deficiencies in the detection, treatment, and control of hypertension before hospitalization have been shown by a survey of 185 patients admitted for various surgical procedures unrelated to hospitalization.
Journal ArticleDOI