Journal ArticleDOI
Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography
TLDR
In this paper, the axial point spread function of optical coherence tomography for Gaussian intensity profiles emitted from and coupled back into singlemode fibers for signals from a scattering medium was determined.Abstract:
The authors studied the axial point spread function of optical coherence tomography for Gaussian intensity profiles emitted from and coupled back into single-mode fibers for signals from a scattering medium. The determined Rayleigh length of the axial point spread function was roughly twice the one measured from the reflection of a mirror. Using the measured point spread function in combination with the single backscatter model allowed determination of the attenuation coefficient of the suspension.read more
Citations
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Journal Article
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal ArticleDOI
Optical coherence tomography patterns of stent restenosis
Nieves Gonzalo,Patrick W. Serruys,Takayuki Okamura,Heleen M.M. van Beusekom,Hector M. Garcia-Garcia,Gijs van Soest,Wim J. van der Giessen,Evelyn Regar +7 more
TL;DR: The ability of OCT to identify differential patterns of restenotic tissue after stenting could help in understanding the mechanism of stent restenosis.
Journal ArticleDOI
Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography
TL;DR: By providing localized, per-pixel attenuation coefficients, this method enables tissue characterization based on attenuation coefficient estimates from OCT data, effectively removing common imaging artifacts such as shadowing.
Journal ArticleDOI
Gold nanocages as contrast agents for spectroscopic optical coherence tomography.
TL;DR: Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes.
Journal ArticleDOI
Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging.
Gijs van Soest,Thadé P. M. Goderie,Evelyn Regar,Senada Koljenović,Geert L. J. H. van Leenders,Nieves Gonzalo,Sander van Noorden,Takayuki Okamura,Brett E. Bouma,Guillermo J. Tearney,J. Wolter Oosterhuis,Patrick W. Serruys,Anton F. W. van der Steen +12 more
TL;DR: This work presents a framework to enable systematic and automatic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient mu(t) of the tissue, and successfully applies the algorithm to OCT patient data.
References
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Journal ArticleDOI
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Mark E. Brezinski,Brett E. Bouma,Brett E. Bouma,Stephen A. Boppart,Stephen A. Boppart,Costas Pitris,Costas Pitris,James F. Southern,James F. Southern,James G. Fujimoto,James G. Fujimoto +12 more
TL;DR: Optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, and was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal Article
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal ArticleDOI
Imaging of macular diseases with optical coherence tomography.
Carmen A. Puliafito,Michael R. Hee,Charles P. Lin,Elias Reichel,Joel S. Schuman,Jay S. Duker,Joseph A. Izatt,Eric A. Swanson,James G. Fujimoto +8 more
TL;DR: Optical coherence tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.
Journal ArticleDOI
In vivo ultrahigh-resolution optical coherence tomography.
Wolfgang Drexler,Uwe Morgner,Franz X. Kärtner,Costas Pitris,Stephen A. Boppart,Xingde Li,Erich P. Ippen,James G. Fujimoto +7 more
TL;DR: To overcome depth-of-field limitations the authors perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth, which is to their knowledge the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.
Journal ArticleDOI
In vivo retinal imaging by optical coherence tomography.
Eric A. Swanson,Joseph A. Izatt,Michael R. Hee,David Huang,Charles P. Lin,Joel S. Schuman,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: These images represent the highest depth resolution in vivo retinal images to date and are to the authors' knowledge the first in vivo measurements of human retinal structure with optical coherence tomography.