Open AccessJournal Article
Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality
Marc R. Larochelle,Dana Bernson,Thomas Land,Thomas J. Stopka,Na Wang,Ziming Xuan,Sarah M. Bagley,Jane M. Liebschutz,Alexander Y. Walley +8 more
TLDR
This study sought to determine whether treatment with MOUD, including receipt of MMT, buprenorphine, or naltrexone, was associated with reduced risk for all-cause and opioid-related mortality.Abstract:
Patients who survive an opioid overdose are at increased risk for subsequent nonfatal and fatal events. This study evaluated overdose survivors to determine whether use of medications for opioid us...read more
Citations
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Journal ArticleDOI
Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder
Sarah E. Wakeman,Marc R. Larochelle,Marc R. Larochelle,Omid Ameli,Christine E. Chaisson,Jeffrey Thomas McPheeters,William H. Crown,Francisca Azocar,Darshak M. Sanghavi +8 more
TL;DR: Treatment with buprenorphine or methadone was associated with reductions in overdose and serious opioid-related acute care use compared with other treatments, and strategies to address the underuse of MOUD are needed.
Journal ArticleDOI
Prevention and Treatment of Opioid Misuse and Addiction: A Review.
TL;DR: The factors that triggered the opioids crisis and its further evolution are analyzed, along with the interventions to manage and prevent opioid use disorder (OUD), which are fundamental for curtailing the opioid crisis.
BookDOI
Medications for Opioid Use Disorder Save Lives
Michelle Mancher,Alan I. Leshner +1 more
TL;DR: In this article, the evidence base on medication assisted treatment (MAT) for opioid use disorder (OUD) is examined and the available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Journal ArticleDOI
Opioid use disorder.
John Strang,John Strang,Nora D. Volkow,Louisa Degenhardt,Matthew Hickman,Kimberly Johnson,George F. Koob,Brandon D.L. Marshall,Mark W. Tyndall,Sharon L. Walsh +9 more
TL;DR: The risk factors of opioid use disorder, together with its epidemiology, mechanisms, diagnosis and treatment, are discussed, including community preventive strategies, harm reduction interventions to reduce adverse sequelae from ongoing use and mutual aid groups.
Journal ArticleDOI
Prevention of Prescription Opioid Misuse and Projected Overdose Deaths in the United States.
Qiushi Chen,Qiushi Chen,Marc R. Larochelle,Davis T. Weaver,Davis T. Weaver,Anna P. Lietz,Peter P. Mueller,Sarah F Mercaldo,Sarah E. Wakeman,Kenneth A. Freedberg,Tiana J. Raphel,Amy B. Knudsen,Pari V. Pandharipande,Jagpreet Chhatwal +13 more
TL;DR: Prevention of prescription opioid misuse alone is projected to have a modest effect on lowering opioid overdose deaths in the near future, and multipronged approach is needed to dramatically change the course of the epidemic.
References
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Journal ArticleDOI
Sensitivity Analysis in Observational Research: Introducing the E-Value
Tyler J. VanderWeele,Peng Ding +1 more
TL;DR: An important approach to evaluating evidence for causation in the face of unmeasured confounding is sensitivity analysis (or bias analysis), and it is proposed that observational studies start reporting the E-value, a new measure related to evidence for causality.
Journal ArticleDOI
Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015.
TL;DR: In an effort to target prevention strategies to address the rapidly changing epidemic, CDC examined overall drug overdose death rates during 2010-2015 and opioid overdosedeath rates during 2014-2015 by subcategories (natural/semisynthetic opioids, methadone, heroin, and synthetic opioids other than methad one).
Journal ArticleDOI
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies
Luis Sordo,Luis Sordo,Gregorio Barrio,María J. Bravo,B. Iciar Indave,Louisa Degenhardt,Louisa Degenhardt,Lucas Wiessing,Marica Ferri,Roberto Pastor-Barriuso +9 more
TL;DR: Retention in methadone and buprenorphine treatment is associated with substantial reductions in the risk for all cause and overdose mortality in people dependent on opioids.
Journal ArticleDOI
Medication-Assisted Therapies — Tackling the Opioid-Overdose Epidemic
TL;DR: The Department of Health and Human Services is working to reduce opioid abuse while ensuring appropriate access to opioids, one key element of the solution is greater use of medication-assisted therapies for addiction.
Journal ArticleDOI
Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial
Gail D'Onofrio,Patrick G. O'Connor,Michael V. Pantalon,Marek C. Chawarski,Susan H. Busch,Patricia H. Owens,Steven L. Bernstein,David A. Fiellin +7 more
TL;DR: Among opioid-dependent patients, ED-initiated buprenorphine treatment vs brief intervention and referral significantly increased engagement in addiction treatment, reduced self-reported illicit opioid use, and decreased use of inpatient addiction treatment services but did not significantly decrease the rates of urine samples that tested positive for opioids or of HIV risk.
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