Journal ArticleDOI
Mesenchymal cells from the human embryonic palate are highly responsive to epidermal growth factor
Toshiyuki Yoneda,Robert M. Pratt +1 more
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An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity, suggesting that epider mal growth factor may play a key role in development of various human embryonic and fetal tissues.Abstract:
An established line of mesenchymal cells from the human embryonic palate is highly sensitive to the stimulatory effect of epidermal growth factor on growth, labeled thymidine incorporation, and ornithine decarboxylase activity. The results suggest that epidermal growth factor may play a key role in development of various human embryonic and fetal tissues.read more
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Journal ArticleDOI
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch,Stephen E. Gould,Suzie J. Scales,Tracy Tang,Hua Tian,Christina P. Ahn,Derek Marshall,Ling Fu,Thomas Januario,Dara Y. Kallop,Michelle Nannini-Pepe,Karen Kotkow,James C. Marsters,Lee L. Rubin,Frederic J. de Sauvage +14 more
TL;DR: This article showed that although ligand-dependent activation of the hedgehog signalling pathway has been associated with tumorigenesis in a number of human tissues, Hh ligands failed to activate signalling in tumour epithelial cells.
Journal ArticleDOI
Role of transforming growth factor-beta in the development of the mouse embryo.
U. Heine,E. F. Munoz,Kathleen C. Flanders,L R Ellingsworth,H.-Y. P. Lam,Nancy L. Thompson,Anita B. Roberts,Michael B. Sporn +7 more
TL;DR: Using immunohistochemical methods, the role of transforming growth factor-beta (TGF-beta) in the development of the mouse embryo is investigated and its ability to control both synthesis and degradation of both structural and adhesion molecules of the extracellular matrix is discussed.
Book ChapterDOI
Cellular Biology and Biochemistry of the Retinoids
TL;DR: In this paper, the cellular biology and biochemistry of the retinoids are discussed and the effects of retinoid on cell differentiation in many different types of epithelia.
Book ChapterDOI
The Epidermal Growth Factor Family
Graham Carpenter,M. I. Wahl +1 more
TL;DR: Histological studies indicated that the precocious eyelid opening in “factor-treated” animals was the consequence of a generalized increase in epidermal thickening and keratinization (Cohen and Elliott 1963).
Journal ArticleDOI
Human cytotrophoblast invasion is up-regulated by epidermal growth factor: Evidence that paracrine factors modify this process
Kathryn E. Bass,Donald W. Morrish,Donald W. Morrish,Iris Roth,Iris Roth,Damyanti Bhardwaj,Damyanti Bhardwaj,Robert N. Taylor,Robert N. Taylor,Yan Zhou,Yan Zhou,Susan J. Fisher +11 more
TL;DR: It is concluded that maternal ligands that interact with the EGF receptor could play an important role by up-regulating trophoblast invasion, particularly during the early stages of pregnancy.
References
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Journal ArticleDOI
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David Barnes,Gordon Sato +1 more
Journal ArticleDOI
Nerve growth factor receptors on human melanoma cells in culture
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