Citations
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Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
TL;DR: Encouraging results indicate that MSC-MVs have similar protective and reparative properties as their cellular counterparts in tissue repair and possibly anti-cancer therapy, and represent a promising opportunity to develop novel cell-free therapy approaches that might overcome the obstacles and risks associated with the use of native or engineered stem cells.
Journal ArticleDOI
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
TL;DR: The full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease.
Journal ArticleDOI
Exosomes/miRNAs as mediating cell-based therapy of stroke.
Hongqi Xin,Yi Li,Michael Chopp +2 more
TL;DR: The present review focuses on the paracrine mechanism of MSC exosomes, and the regulation and transfer of exosome content, especially the packaging andTransfer of miRNAs which enhance tissue repair and functional recovery.
Journal ArticleDOI
Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury.
Karla Drommelschmidt,Meray Serdar,Ivo Bendix,Josephine Herz,Frederik Bertling,Sebastian Prager,Matthias Keller,Anna Kristin Ludwig,Vikas Duhan,Stefan Radtke,Kyra de Miroschedji,Peter A. Horn,Yohan van de Looij,Bernd Giebel,Ursula Felderhoff-Müser +14 more
TL;DR: MSC-EVs ameliorate inflammation-induced cellular damage in a rat model of preterm brain injury and may serve as a novel therapeutic option by prevention of neuronal cell death, restoration of white matter microstructure, reduction of gliosis and long-term functional improvement.
Journal ArticleDOI
Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues
TL;DR: The concept of “force isotropy” relevant to cytoskeletal forces and relevant to extracellular loads acting on cells is introduced, to provide an interpretation of how the effects of insoluble biophysical signals can be used to direct stem cells fate in vitro.
References
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Journal ArticleDOI
Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
TL;DR: Encouraging results indicate that MSC-MVs have similar protective and reparative properties as their cellular counterparts in tissue repair and possibly anti-cancer therapy, and represent a promising opportunity to develop novel cell-free therapy approaches that might overcome the obstacles and risks associated with the use of native or engineered stem cells.
Journal ArticleDOI
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
TL;DR: The full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease.
Journal ArticleDOI
Exosomes/miRNAs as mediating cell-based therapy of stroke.
Hongqi Xin,Yi Li,Michael Chopp +2 more
TL;DR: The present review focuses on the paracrine mechanism of MSC exosomes, and the regulation and transfer of exosome content, especially the packaging andTransfer of miRNAs which enhance tissue repair and functional recovery.
Journal ArticleDOI
Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury.
Karla Drommelschmidt,Meray Serdar,Ivo Bendix,Josephine Herz,Frederik Bertling,Sebastian Prager,Matthias Keller,Anna Kristin Ludwig,Vikas Duhan,Stefan Radtke,Kyra de Miroschedji,Peter A. Horn,Yohan van de Looij,Bernd Giebel,Ursula Felderhoff-Müser +14 more
TL;DR: MSC-EVs ameliorate inflammation-induced cellular damage in a rat model of preterm brain injury and may serve as a novel therapeutic option by prevention of neuronal cell death, restoration of white matter microstructure, reduction of gliosis and long-term functional improvement.
Journal ArticleDOI
Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues
TL;DR: The concept of “force isotropy” relevant to cytoskeletal forces and relevant to extracellular loads acting on cells is introduced, to provide an interpretation of how the effects of insoluble biophysical signals can be used to direct stem cells fate in vitro.