Journal ArticleDOI
Metabolic control theory: a structural approach
TLDR
This paper emphasizes the structural characterizations and properties of the systems which depend only on the structure of the metabolic network, and not on the reaction kinetics, and shows the efficiency of such a structural approach.About:
This article is published in Journal of Theoretical Biology.The article was published on 1988-11-21. It has received 539 citations till now. The article focuses on the topics: Metabolic network.read more
Citations
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Journal ArticleDOI
Toward a science of metabolic engineering
TL;DR: Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates.
Journal ArticleDOI
The small world inside large metabolic networks
Andreas Wagner,David A. Fell +1 more
TL;DR: In this article, a graph theoretical analysis of the E. coli metabolic network was performed and it was shown that the connectivity of the metabolites follows a power law, another unusual but by no means rare statistical distribution, which provides an objective criterion for the centrality of the tricarboxylic acid cycle to metabolism.
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Metabolic control analysis: a survey of its theoretical and experimental development.
TL;DR: The discoveries of feedback inhibition, co-operativity and covalent modification in enzymes, and of mechanisms for the control of enzyme synthesis and degradation, have disclosed a repertoire of molecular effects that potentially alter the fluxes in metabolic pathways.
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Theory for the Systemic Definition of Metabolic Pathways and their use in Interpreting Metabolic Function from a Pathway-Oriented Perspective
TL;DR: This study presents the theoretical foundations for the identification of the unique set of systemically independent biochemical pathways, termed extreme pathways, based on system stochiometry and limited thermodynamics, and can be used to represent any flux distribution achievable by the metabolic network.
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On elementary flux modes in biochemical reaction systems at steady state
TL;DR: It is shown that for systems in which all flux- have fixed signs, all elementary modes are given by the generating vectors of a convex cone and can, thus, be computed by an existing algorithm.
References
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Journal ArticleDOI
A Linear Steady‐State Treatment of Enzymatic Chains
TL;DR: A theoretical analysis of linear enzymatic chains is presented and three cardinal terms are proposed for the quantitative description of enzyme systems, including the effector strength, which defines the dependence of the velocity of an enzyme on the concentration of an effector.
Journal Article
The control of flux.
Henrik Kacser,J A Burns +1 more
TL;DR: Molecular Enzymology Group Colloquium Organized by D. Fell (School of Biological and Molecular Sciences, Oxford Brooke University) and D. Kell (Department of Biological Sciences, University College, Wales, Aberystwyth) as discussed by the authors.
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Metabolic regulation and mathematical models
TL;DR: This chapter discusses different types of models and the methods of modeling, which are useful for the deduction of the essential relations in metabolism that constitute a characteristic dynamic structure.
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Metabolic control and its analysis. Additional relationships between elasticities and control coefficients.
David A. Fell,Herbert M. Sauro +1 more
TL;DR: Algebraic solutions have been used to determine the factors responsible for the degree of amplification of flux control coefficients by substrate cycles and to show that it is possible to derive expressions for the elasticities of a group of enzymes.
Metabolic control theory: its role in microbiology and biotechnology (Flux control; optimisation; elasticity; concentration control; productivity; metabolism; genetic engineering)
TL;DR: The metabolic control theory developed by Kacser, Burns, Heinrich and Rapoport can provide a rational and quantitative basis for the description and improvement of such processes.