Journal ArticleDOI
Metabolic stereoisomeric inversion of ibuprofen in mammals.
TLDR
In vitro findings suggest that the step of acyl-CoA formation assume a pivotal role in controlling the stereoselectivity and efficiency of the in vivo metabolism of ibuprofen isomerization in guinea pigs.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-07-12. It has received 97 citations till now.read more
Citations
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Journal ArticleDOI
The Challenge of Atropisomerism in Drug Discovery
TL;DR: This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.
Journal ArticleDOI
Assessing Atropisomer Axial Chirality in Drug Discovery and Development
Steven R. LaPlante,Lee Fader,Keith R. Fandrick,Daniel R. Fandrick,Oliver Hucke,Ray Kemper,Stephen P. F. Miller,Paul J. Edwards +7 more
TL;DR: Assessing Atropisomer Axial Chirality in Drug Discovery and Development Steven R. F. Fandrick, Oliver Hucke, Ray Kemper, Stephen P. Miller, and Paul J. Edwards assess the importance of chiral consistency in drug discovery and development.
Journal ArticleDOI
Clinical pharmacokinetics of ibuprofen. The first 30 years
TL;DR: A relationship between ibuprofen plasma concentrations and analgesic and antipyretic effects has been elucidated and a proposed site of action for nonsteroidal anti-inflammatory drugs is proposed.
Journal ArticleDOI
Atropisomerie als Herausforderung in der Medikamentenentwicklung
Journal ArticleDOI
Purification and properties of an alpha-methylacyl-CoA racemase from rat liver.
TL;DR: A very sensitive and convenient radiometric assay, with 2-methyl[2-(3)H]acyl-CoAs as substrates, was developed, which showed the mechanism involves abstraction of a proton in the alpha-position of the fatty acid.
References
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Journal ArticleDOI
Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids.
Arthur Kornberg,W.E. Pricer +1 more
Journal ArticleDOI
The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences
Andrew J. Hutt,John Caldwell +1 more
Journal ArticleDOI
The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences.
TL;DR: The biological consequences of the metabolic chiral inversion and enantioselective disposition of the 2-arylpropionates have been summarized in terms of their implications for the development and use of safer and more effective drugs of this class.
Journal ArticleDOI
The specificity of triglyceride synthesis from diglycerides in chicken adipose tissue.
P Goldman,P R Vagelos +1 more
TL;DR: The specificity of esterification of diglycerides is examined in a particulate enzyme system obtained from chicken fat which gives a relatively high yield with respect to both coenzyme A and the fatty acid.
Journal ArticleDOI
Renal Effects of Ibuprofen, Piroxicam, and Sulindac in Patients with Asymptomatic Renal Failure: A Prospective, Randomized, Crossover Comparison
TL;DR: In this article, the effects of three chemically distinct nonsteroidal anti-inflammatory drugs (NSAIDs) on renal function in patients with asymptomatic, mild but stable chronic renal failure were evaluated.