Journal ArticleDOI
Metal chelates of streptomycin.
TLDR
The copper chelate, found to be relatively uncontaminated with metal hydroxide, exhibited more prolonged blood levels in guinea pigs than streptomycin sulfate, but also a greater toxicity.Abstract:
Streptomycin has been found to undergo chelation with several metals in aqueous solution. Evidence for chelate formation is provided by a drop in pH during the formation, production of characteristic colors, decreased solubility in water, and absence of metal ions in the solution. The copper chelate, found to be relatively uncontaminated with metal hydroxide, exhibited more prolonged blood levels in guinea pigs than streptomycin sulfate, but also a greater toxicity.read more
Citations
More filters
Journal ArticleDOI
NMR studies of iron-gentamicin complexes and the implications for aminoglycoside toxicity
TL;DR: The results explain the previously reported biphasic nature of gentamicin-dependent lipid peroxidation, suggesting that a 1:1 Gentamicin:iron complex is active and a 2:1 complex is inert with respect to peroxidated.
Journal ArticleDOI
Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration.
TL;DR: These simulations indicate that whereas ethambutol forms metal complexes only to a limited extent in vivo, EDBA competes effectively under physiological conditions for copper(II) and zinc(II).
Journal ArticleDOI
Metal binding tendencies of various antibiotics
TL;DR: Evidence is presented to confirm the presence of penicilloic acid in reaction mixtures initially containing penicillin G or V and cupric ions, and to establish that the reaction follows second order kinetics and ceases when all available cupric ion has been consumed.
Journal ArticleDOI
Effect of streptomycin on greening and biosynthesis in Euglena gracilis.
TL;DR: It is suggested that streptomycin has a general effect on biosynthesis and that its inhibition of greening is not due to a specific inhibition of chloroplast formation, but is merely one consequence of the effect on general biosynthesis.
Journal ArticleDOI
Enzymatic properties of a phage-induced lysin affecting group A streptococci.
C. C. Doughty,James A. Hayashi +1 more
TL;DR: It is concluded that the enzymatic process of lysis of isolated cell walls is not identical to the more complex process resulting inLysis of intact cells.
References
More filters