Patent
Methods of detecting micrometastasis of prostate cancer.
TLDR
In this paper, a method of diagnosing prostate metastasis is provided by the present invention whereby RNA from a patient's blood is isolated and amplified using a pair of primers which are complementary to regions of the prostate specific antigen gene.Abstract:
A method of diagnosing prostate metastasis is provided by the present invention whereby RNA from a patient's blood is isolated and amplified using a pair of primers which are complementary to regions of the prostate specific antigen gene. The presence or absence of amplified RNA is detected and the presence of amplified RNA is indicative micrometastasis of prostate cancer.read more
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MicroRNA Signatures in Human Ovarian Cancer
TL;DR: In this paper, the authors presented novel methods for the diagnosis of ovarian cancer using at least one miR selected from miR-200b, miR -200b and miR −200c.
PatentDOI
Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
TL;DR: In this paper, microRNA expression profiling of three types of chronic lymphocytic leukemia (CLL) was carried out and it was shown that Tcl1 expression is regulated by miR-29 and miR]-181, two microRNAs differentially expressed in CLL.
PatentDOI
MicroRNA fingerprints during human megakaryocytopoiesis
TL;DR: In this paper, a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOX-A1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXa1 in the subject.
PatentDOI
Prostate-specific membrane antigen
TL;DR: In this article, an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen was used for detecting hematogenous micrometastic tumor cells of a subject performing the polymerase chain reaction (PCR) on samples of the subjet using primers of said antigen.
Patent
Reagents and methods useful for detecting diseases of the breast
Patricia A. Billing-Medel,Maurice Cohen,Tracey L. Colpitts,Paula N. Friedman,Julian Gordon,Edward N. Granados,Steven C. Hodges,Michael R. Klass,Jon D. Kratochvil,Lisa Roberts-Rapp,John C. Russell,Stephen D. Stroupe +11 more
TL;DR: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described in this paper, which are useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
The function of the vertebral veins and their rôle in the spread of metastases
TL;DR: In this paper, the authors examined the role of the vertebral veins in normal physiology and found that the distribution of these paradoxic metastases is not at all that of the nerve sheaths of the area as suggested by Warren et al.
Journal ArticleDOI
Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radical Prostatectomy Treated Patients
Thomas A. Stamey,John N. Kabalin,John E. McNeal,Iain M. Johnstone,Fuad S. Freiha,Elise A. Redwine,Norman Yang +6 more
TL;DR: No difference in preoperative or postoperative prostate specific antigen levels, cancer volume, seminal vesicle invasion or incidence of pelvic lymph node metastasis was seen, providing the first quantitative evidence that small amounts of capsular penetration may not be of biological or prognostic significance.
Journal Article
Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation.
TL;DR: It is suggested that dynamics of hematogenously initiated metastases depend strongly on the entry rate of tumor cell clumps into the circulation, which in turn is intimately linked to tumor vascularization.
Journal ArticleDOI
A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.
TL;DR: The structural protein of human seminal coagulum, the predominant protein in seminal vesicle secretion, was rapidly cleaved by the prostatic enzyme, which suggests that this seminal vESicle protein may serve as the physiological substrate for the protease.