Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TLDR
The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.Abstract:
The ability to find one's way depends on neural algorithms that integrate information about place, distance and direction, but the implementation of these operations in cortical microcircuits is poorly understood. Here we show that the dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment. Its key unit is the 'grid cell', which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment. Grids of neighbouring cells share a common orientation and spacing, but their vertex locations (their phases) differ. The spacing and size of individual fields increase from dorsal to ventral dMEC. The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment.read more
Citations
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Journal ArticleDOI
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
Journal ArticleDOI
Path integration and the neural basis of the 'cognitive map'
Bruce L. McNaughton,Bruce L. McNaughton,Francesco P. Battaglia,Ole Jensen,Edvard I. Moser,May-Britt Moser +5 more
TL;DR: Theoretical studies suggest that the medial entorhinal cortex might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation.
Journal ArticleDOI
Place Cells, Grid Cells, and the Brain's Spatial Representation System
TL;DR: How place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory is reviewed.
Journal ArticleDOI
Coordinated memory replay in the visual cortex and hippocampus during sleep
Daoyun Ji,Matthew A. Wilson +1 more
TL;DR: It is found that spiking patterns not only in the cortex but also in the hippocampus were organized into frames, defined as periods of stepwise increase in neuronal population activity.
Journal ArticleDOI
Pattern separation in the dentate gyrus and CA3 of the hippocampus.
TL;DR: These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3.
References
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Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
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TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
Journal ArticleDOI
The hippocampus as a cognitive map
TL;DR: Introduction to cognitive PDF heidegger and cognitive science PDF group cognitive therapy Group cognitive therapy for addictions handbook of brief cognitive behavioral therapy gurwitschs relevancy for cognitive science, and imagery creativity and discovery a cognitive perspective.
Journal ArticleDOI
The medial temporal lobe
TL;DR: This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.
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The organization of learning
TL;DR: It is argued compellingly that experimental psychologists should begin to view the phenomena of learning within a framework that utilizes as the proper unit of analysis the computation and storage of a quantity, rather than the formation of an association that has been the basis of traditional learning theory.