Journal ArticleDOI
Modifier theory of meiotic drive: Is Mendelian segregation stable?
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TLDR
It is shown that a polymorphism based on Mendelian segregation is never stable for any recombination frequencies between 0 and 1 2, and that, for tight linkage between the main locus and the modifiers locus, the modifier locus tends towards heterozygosity.About:
This article is published in Theoretical Population Biology.The article was published on 1976-10-01. It has received 41 citations till now. The article focuses on the topics: Meiotic drive & Locus (genetics).read more
Citations
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Chromosome Inversions, Local Adaptation and Speciation
TL;DR: The evolution of inversions that capture locally adapted alleles when two populations are exchanging migrants or hybridizing is studied to cause loci responsible for adaptive species-specific differences to map to inversions.
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Divergence of meiotic drive-suppression systems as an explanation for sex-biased hybrid sterility and inviability.
TL;DR: It is shown that divergence of meiotic drive systems can explain the two generalizations about speciation even if large departures from Mendelian segregation are rarely observed.
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On the changing concept of evolutionary population stability as a reflection of a changing point of view in the quantitative theory of evolution.
TL;DR: This paper tries to relate the recent confusion, concerning concepts of population stability, with a more serious, though not that well-recognized, confusion in the modern analytic approach to population dynamics and quantitative evolution.
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Why is Mendelian segregation so exact
TL;DR: Mathematical theory shows that unlinked modifiers that change the degree of distortion in the direction of Mendelism always increase in the population, which provides a mechanism for removing cheaters and preserving the honesty of the Mendelian gene-shuffle.
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The role of meiotic drive in hybrid male sterility
TL;DR: The recent empirical evidence for a link between drive and hybrid male sterility is discussed, suggesting a possible mechanistic explanation for this link in the context of chromatin remodelling and the population genetics of drive that allow it to contribute to speciation are revisit.
References
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Journal ArticleDOI
Towards a theory of the evolution of modifier genes
TL;DR: A wide variety of random mating systems are subject to selection with modifiers operating, in different cases, on mutation rates, migration between subpopulations, and linkage between other loci, where modifier frequencies evolve in such a way as to maximize the mean fitness of the population at equilibrium.
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Modifier theory and meiotic drive
TL;DR: The evolutionary fate of rare modifiers of recessive lethal segregation distorters has been studied and it is found that suppressors or partial suppressors will always increase in frequency and enhance if linkage is sufficiently tight.
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Population genetics of modifiers of meiotic drive. I. The solution of a special case and some general implications.
TL;DR: It is argued that if there is linkage a stable two locus polymorphism can result and it is suggested that this result explains how the SD system in Drosophila maintains its integrity in natural populations.
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Population genetics of modifiers of meiotic drive. II. Linkage modification in the segregation distortion system
TL;DR: The conditions are found under which the frequency of a new gene altering the recombination fraction between two loci controlling meiotic drive will increase, which may help explain the presence of inversions and duplications in the segregation-distorter system in Drosophila.
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The Evolutionary Development of Modifier Genes
Samuel Karlin,James McGregor +1 more
TL;DR: The main findings of a study of the evolution of modifier gene frequencies in models of deterministic population genetics are presented: a wide variety of random mating systems are subject to selection with modifiers operating, in different cases, on mutation rates, dominance, migration between subpopulations, and linkage between other loci.