Journal ArticleDOI
Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease.
TLDR
NIRS has been applied to measure oxygenation in a variety of tissues including muscle, brain and connective tissue, and more recently it has been used in the clinical setting to assess circulatory and metabolic abnormalities.Abstract:
Near infrared spectroscopy (NIRS) is becoming a widely used research instrument to measure tissue oxygen (O2) status non-invasively. Continuous-wave spectrometers are the most commonly used devices, which provide semi-quantitative changes in oxygenated and deoxygenated hemoglobin in small blood vessels (arterioles, capillaries and venules). Refinement of NIRS hardware and the algorithms used to deconvolute the light absorption signal have improved the resolution and validity of cytochrome oxidase measurements. NIRS has been applied to measure oxygenation in a variety of tissues including muscle, brain and connective tissue, and more recently it has been used in the clinical setting to assess circulatory and metabolic abnormalities. Quantitative measures of blood flow are also possible using NIRS and a light-absorbing tracer, which can be applied to evaluate circulatory responses to exercise along with the assessment of tissue O2 saturation. The venular O2 saturation can be estimated with NIRS by applying venous occlusion and measuring changes in oxygenated vs. total hemoglobin. These various measurements provide the opportunity to evaluate several important metabolic and circulatory patterns in very localized regions of tissue and may be fruitful in the study of occupational syndromes and a variety of diseases.read more
Citations
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Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
TL;DR: Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity.
Journal ArticleDOI
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
TL;DR: Cellular and molecular consequences of physioxia versus normoxia and hypoxia, and the role of microRNAs in Hypoxia‐dependent regulations are summarized.
Journal ArticleDOI
Principles, techniques, and limitations of near infrared spectroscopy.
TL;DR: NIRS is a noninvasive and relatively low-cost optical technique that is becoming a widely used instrument for measuring tissue O2 saturation, changes in hemoglobin volume and, indirectly, brain/muscle blood flow and muscle O2 consumption.
Journal ArticleDOI
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease
François Maltais,Marc Decramer,Richard Casaburi,Esther Barreiro,Yan Burelle,Richard Debigaré,P. N. Richard Dekhuijzen,Frits M.E. Franssen,Ghislaine Gayan-Ramirez,Joaquim Gea,Harry R. Gosker,Rik Gosselink,Maurice Hayot,Sabah N. A. Hussain,Wim Janssens,Micheal I. Polkey,Josep Roca,Didier Saey,Annemie M. W. J. Schols,Martijn A. Spruit,Michael C Steiner,Tanja Taivassalo,Thierry Troosters,Ioannis Vogiatzis,Peter D. Wagner +24 more
TL;DR: The purpose of this document is to update the 1999 ATS/ERS statement on limb muscle dysfunction in COPD with important advances in the understanding of the extent and nature of the structural alterations in limb muscles in patients with COPD.
Journal ArticleDOI
Wearable sensors: modalities, challenges, and prospects
Jason Heikenfeld,Andrew J. Jajack,John A. Rogers,Philipp Gutruf,Limei Tian,Tingrui Pan,Ronald A. Li,Michelle Khine,Jitae Kim,Joseph Wang +9 more
TL;DR: A deeper understanding of the fundamental challenges faced for wearable sensors and of the state-of-the-art for wearable sensor technology, the roadmap becomes clearer for creating the next generation of innovations and breakthroughs.
References
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UNIT 9.7 Oxidative Metabolism
TL;DR: These protocols are applicable to many different cell types, but provide detailed information on using neutrophils, highly reactive cells that produce vast quantities of ROS.