Journal ArticleDOI
Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria.
J. S. M. Peiris,Sunil Premawansa,M. B. Ranawaka,Preethi V. Udagama,Munasinghe Yd,Nanayakkara Mv,Gamage Cp,Richard Carter,Peter H. David,Kamini N. Mendis +9 more
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TLDR
It is reported that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P.vivax in humans can have the opposite effect and enhance the level of malaria infection in the mosquitoes.Abstract:
Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.read more
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.
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Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
Teun Bousema,Chris Drakeley +1 more
TL;DR: How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.
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Current Status of Malaria and Potential for Control
TL;DR: This review considers the factors which have contributed to this gloomy picture of malaria, including those which relate to the vector, the female anopheline mosquito; to human activity such as creating new mosquito breeding sites, the impact of increased numbers of people, and how their migratory behavior can increase the incidence and spread of malaria.
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Malaria vaccines
TL;DR: Findings from intensive studies of the immune response to the malaria parasite in humans and in models may suggest that an effective vaccine is “just around the corner,” but what are the scientific obstacles?
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Serodiagnostics for Severe Acute Respiratory Syndrome-Related Coronavirus 2 : A Narrative Review.
Matthew P. Cheng,Cedric P. Yansouni,Nicole E. Basta,Michaël Desjardins,Sanjat Kanjilal,Katryn Paquette,Chelsea Caya,Makeda Semret,Caroline Quach,Michael Libman,Laura Mazzola,Jilian A. Sacks,Sabine Dittrich,Jesse Papenburg +13 more
TL;DR: Key use cases for SARS-CoV-2 antibody detection tests and their application to serologic studies are discussed, currently available assays are reviewed, key areas of ongoing research are highlighted, and potential strategies for test implementation are proposed.