Journal ArticleDOI
Morphine and met-enkephalin effects on sural Adelta afferent terminal excitability.
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TLDR
Results indicate that morphine and met-enkephalin hyperpolarize Adelta sural afferent terminals and facilitate the terminal depolarization during presynaptic inhibition, which may be, at least partly, responsible for the analgesic action of these agents.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-08-01. It has received 51 citations till now.read more
Citations
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Journal ArticleDOI
Presynaptic inhibition in the vertebrate spinal cord revisited.
Pablo Rudomín,Robert F. Schmidt +1 more
TL;DR: Intaspinal terminals of sensory fibers are not hard-wired conductors of the information generated in their peripheral sensory receptors, but dynamic systems that convey information that can be selectively addressed by central mechanisms to specific neuronal targets.
Journal ArticleDOI
Dorsal root potentials and dorsal root reflexes: a double-edged sword.
TL;DR: The conversion of an inhibitory process, presynaptic inhibition, to an excitatory one by DRRs can lead to pathological consequences, and the consquences of this increase in DRRs may include exacerbate of hyperalgesia as well as of peripheral inflammation.
Journal ArticleDOI
Presynaptic inhibition of muscle spindle and tendon organ afferents in the mammalian spinal cord
TL;DR: Evidence indicates that the synaptic effectiveness of muscle spindle afferents associated with spinal motoneurones could be diminished by the activation of nerves from flexor muscles is controlled by separate sets of GABAergic interneurones synapsing directly with the intraspinal terminals of the afferent fibres.
Book
Control of Nociceptive Transmission in the Spinal Cord
TL;DR: Soldering method comprises placing a cadmium-zinc-lead solder on a copper base and exposing the solder joint to about 200 DEG C. for at least one hour to produce a copper-cadmium -zinc ternary interface barrier layer which inhibits migration.
References
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Journal ArticleDOI
Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more
TL;DR: It is reported here that opiate analgesics are able to suppress the stimulus-evoked release of SP, which may represent a mechanism for the direct spinal analgesic actions of opiates.
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Effects of substance P on functionally identified units in cat spinal cord
TL;DR: Results suggest that substance P may be involved in excitatory spinal processes and that its actions may be associated specifically with nociception.
Journal ArticleDOI
Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section.
TL;DR: A localization of receptor binding to the upper dorsal horn is reported and a fall in opiate receptor binding in this area following dorsal root section of rhesus monkey spinal cord is described.
Journal ArticleDOI
Autoradiographic localization of the opiate receptor in rat brain
TL;DR: One hour after injection of the potent opiate antagonist 3 H-diprenorphine 75–85% of the drug is associated with opiate receptor sites, and dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantium gelatinosa.
Journal ArticleDOI
Suppression of transmission of nociceptive impulses by morphine: Selective effects of morphine administered in the region of the substantia gelatinosa
TL;DR: Both the selective action of morphine on nociceptive responses and the reversal of this action by intravenous naloxone suggest that the opiate receptor present in the substantia gelatinosa is relevant to analgesia produced by opiates given systemically.
Related Papers (5)
Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section.
Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more