Showing papers in "Life Sciences in 1975"
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TL;DR: It is an opioid agonist on the guinea pig myenteric plexus-longitudinal muscle preparation, and on the mouse vas deferens, and it binds to opiate receptors in homogenates of Guinea pig brain.
2,271 citations
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512 citations
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TL;DR: A procedure for measuring picogram quantities of norepinephrine has been developed utilizing partially purified bovine adrenal phenylethanolamine-N-methyl-transferase and 3 [H]-S-adenosyl-methionine, applicable to many body tissues and fluids, including brain and plasma.
497 citations
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TL;DR: The present study demonstrates that induction of excessive grooming is dose-dependent and independent of the endocrine system, and structure-activity studies show that ACTH1–24, ACTh1–16-NH2, ACTH 1–16, α-MSH and βp- MSH are equipotent.
386 citations
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TL;DR: 3H-Dopamine and 3H-haloperidol bind with high affinity and selectivity to synaptic dopamine receptors in membrane preparations of the calf caudate, and the rank-order of phenothiazines and related agents as well as catecholamines in displacing both dopamine and haloperidl binding closely parallels their pharmacological potencies and affinities for the dopamine-sensitive adenylate cyclase.
383 citations
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TL;DR: One hour after injection of the potent opiate antagonist 3 H-diprenorphine 75–85% of the drug is associated with opiate receptor sites, and dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantium gelatinosa.
379 citations
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TL;DR: An endogenous morphine-like substance found in rat and calf brains has a regional distribution correlating with that of opiate receptors, with the highest levels in the caudate and negligible amounts in the cerebellum.
378 citations
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TL;DR: It is concluded that, in terms of adrenal function, there is little evidence that isolation per se constitutes a stress in rats and mice, although there is some evidence that adrenocortical reactivity is increased by housing animals in this manner.
336 citations
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TL;DR: Observations suggest that precursor availability may influence brain ACh synthesis, just as brain tryptophan and tyrosine levels have previously been shown to control the synthesis of brain serotonin and catecholamines.
332 citations
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TL;DR: Cell membranes and intracellular materials are selectively solubilized with 4% sodium deoxycholate to yield morphologically and chemically intact basement membrane preparations and this method appears to be a versatile, nondisruptive procedure.
329 citations
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TL;DR: Synthesis of the pentapeptide having this sequence and exhibiting the properties of natural proctolin confirmed the structure.
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TL;DR: The findings of this study support the proposal that sodium-dependent high affinity choline uptake can be used as a relative measure of the activity of cholinergic neurons in vivo.
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TL;DR: A unique fraction of an apparent molecular weight of 1000 to 1200 dalton, probably identical with that previously found in brain extracts, showed affinity to opiate receptors in synaptic plasma membrane preparations from rat brain and was termed MLF (morphine-like factor).
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TL;DR: Interactions between endogenous enkephalin and exogenous opiate at the opiate receptor are discussed as a possible basis of tolerance and dependence caused by chronic administration of opiates.
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TL;DR: It is suggested that the peptide extracted from the pig brain may have a wide neurophysiological role in the brain and possibly in other tissues.
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TL;DR: It is found that synthesis of brain acetylcholine can be stimulated in vivo by elevating the tissue concentration of its precursor, indicating that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetyl choline.
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TL;DR: It is concluded that acute administration of narcotic drugs results in an inhibition of dopamine-receptor activity while chronic administration of these drugsresults in an increased response of these dopamine receptors to dopamine agonists.
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TL;DR: Proctolin was fully active on TTX-treated or surgically denervated muscle indicating that the proctolin receptors are located on the muscle fibre membrane, and evidence suggests that it may function as an excitatory transmitter substance.
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TL;DR: Lesion studies indicate that histamine-containing neurones constitute an ascending bundle arising from the brain-stem, passing through the lateral hypothalamus, and projecting diffusely into the whole telencephalon, suggesting that histaminergic neurones might be involved, like the monoaminergic ones, in the control of states of wakefulness and sleep.
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TL;DR: Results indicate the importance of intraventricularly released vasopressin on memory processes involved in the maintenance of behavioral homeostasis as indicated by the virtual absence of vasoppressin in the urine.
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TL;DR: Sulpiride appears to be unique in respect to other neuroleptic since according to the experiments reported in this paper it does not block dopamine receptors either in vitro or in vivo.
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TL;DR: It is concluded that the endoperoxides PGG2 and PGH2 are potent smooth muscle stimulants and that they are more effective than their degradation products (PGD 2, PGE2, PGF2a) in some systems.
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TL;DR: At its pH 5.0 optimum, cathepsin B2 behaved as a SH-dependent, non-specific carboxypeptidase by releasing COOH-terminal amino acids from a variety of Cbz-Gly-X substrates and polypeptides such as glucagon, Val-Leu-Ser-Glu-gly, and penta-lysine.
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TL;DR: The concentration of opiate receptors in the brains of mice was determined by means of a naloxone-binding assay and it was found that at least 2 genetic determinants may be involved in regulating the level of opiates receptors.
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TL;DR: The results are compatible with the hypothesis that adenosine depresses neurons by activating an extracellular receptor and that this effect can be blocked by theophylline and caffeine.
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TL;DR: It is observed that d-LSD interacts with considerable affinity at the dopamine receptor, which suggests that it is a mixed agonist-antagonist, which is consistent with its interactions with the dopamine-sensitive adenylate cyclase.
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TL;DR: This is the first demonstration of salsolinol in mammalian tissue during alcohol metabolism, although the alkaloid has been detected in urine of DOPA-treated Parkinsonian patients.
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TL;DR: The prolongation of half-life in the non-smokers was very significant (p), and the half- life following an I.V. aminophylline bolus was 3.6 ± 1.5 hours.
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TL;DR: No significant change in the apparent pA 2 of naloxone in tolerant rats in vivo could be found, indicating that no substantial change inThe affinity for the receptors takes place, and displacement of small amounts of high labeled antagonist by increasing amounts of unlabeled antagonist in mouse brain in vivo offered the possibility of characterizing properties of receptors in the intact animal.