Journal ArticleDOI
Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene.
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TLDR
Morphometric analysis of this animal model further defines the dynamic changes in the mouse ovary in response to DMBA as a dose-dependent decrease in ovarian volume and number of corpora lutea in each ovary.About:
This article is published in Reproductive Toxicology.The article was published on 1992-01-01. It has received 24 citations till now. The article focuses on the topics: DMBA & 7,12-Dimethylbenz[a]anthracene.read more
Citations
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Journal ArticleDOI
Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays
Brad Bolon,Thomas J. Bucci,Alan Warbritton,James J. Chen,Donald R. Mattison,Jerrold J. Heindel +5 more
TL;DR: Morrissey et al. as discussed by the authors used the National Toxicology Program Reproductive Assessment by Continuous Breeding (RACB) bioassays to directly compare differential ovarian follicle counts and reproductive performance for 15 chemicals.
Journal ArticleDOI
Influence of sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies
TL;DR: Follicle counts from 1% or 5% random samples may provide a suitable screen for ovarian toxicity, according to mean numbers of small and growing follicles.
Journal Article
The effect of smoking on oogenesis, fertilization and implantation.
Journal ArticleDOI
Cigarette smoke inhalation affects the reproductive system of female hamsters
TL;DR: Experimental observations show that components in both MS and SS smoke, when delivered at levels comparable to those human smokers receive, can affect the ovary, oviduct, and uterus.
Journal ArticleDOI
Characterization of a Carcinogenesis Rat Model of Ovarian Preneoplasia and Neoplasia
Sherri L. Stewart,Troy D. Querec,Alexander R. Ochman,Briana N. Gruver,Rudi Bao,James S. Babb,Thang S. Wong,Theodoros Koutroukides,Aaron D. Pinnola,Andres J. Klein-Szanto,Thomas C. Hamilton,Christos Patriotis +11 more
TL;DR: Data indicate that this DMBA animal model gives rise to ovarian lesions that closely resemble human ovarian cancer and it is adequate for additional studies on the mechanisms of the disease and its clinical management.
References
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Environmental tobacco smoke. Measuring exposures and assessing health effects
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Cigarette smoking and urinary estrogens.
TL;DR: The estrogen profiles of smokers and nonsmokers were compared to shed light on the mechanisms whereby smoking is associated with early menopause and with a reduction in the risk of breast cancer.
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RELATION BETWEEN SMOKING AND AGE OF NATURAL MENOPAUSE: Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center
TL;DR: The relation of cigarette smoking to natural menopause has been evaluated in two independent sets of data and, at each age from 44 to 53 years, more current smokers were post-menopausal compared to "never" smokers.
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Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study.
TL;DR: There was a consistent and highly significant trend of decreasing fertility with increasing numbers of cigarettes smoked per day and it was estimated that five years after stopping contraception 10.7% of smokers smoking more than 20 cigarettes a day, but only 5.4% of non-smokers, remained undelivered.
Journal ArticleDOI
Magnesium in heart muscle
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